[A follow-up study on children conceived through intracytoplasmic sperm injection.]
ABSTRACT OBJECTIVE: To investigate the perinatal complications, birth defects and growth of children conceived through intracytoplasmic sperm injection (ICSI). METHODS: A total of 575 children conceived by ICSI in our reproductive medical center, were studied. The follow-up study would include items as pregnant complications, neonatal complications, birth defects in perinatal period, subsequently detected birth defects, body weight and body length/height growth. RESULTS: Prematurity and low birth weight of ICSI children were higher in the multiple births than in the singleton births. The rates of materal gestational hypertension, neonatal asphyxia, respiratory distress syndrome, infection diseases were higher in the multiple pregnancies than in the singleton pregnancies (P < 0.05). Eleven ICSI children had died. Ten of them died in the neonatal period and they were preterm infants. One fullterm singleton ICSI child died of hepatoblastoma at the age of 2. The rate of birth defects in perinatal period was higher in ICSI children of multiple pregnancies than in the general population (P < 0.05). The body weight and body length/height of most ICSI children had obtained the standard range between 1 to 3 year-olds. CONCLUSION: The higher rates of perinatal complications in ICSI children were closely related to multiple pregnancies.