Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma.

Hematology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Cancer genetics and cytogenetics (Impact Factor: 1.54). 12/2010; 203(2):328-32. DOI: 10.1016/j.cancergencyto.2010.08.018
Source: PubMed

ABSTRACT Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with MYC, BCL2, and BCL6 rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.

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