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HIV vaccine development: past, present and future.

Merlin L Robb

US Military HIV Research Program, 1600 Gude Drive, Rockville, MD 20850, USA.

Journal Article: IDrugs: the investigational drugs journal (impact factor: 1.93). 12/2010; 13(12):852-6.

Abstract

The search for an HIV vaccine began following the discovery of the virus more than 25 years ago. Despite important progress, an effective vaccine remains an elusive goal that will likely require many more years of R&D to achieve. Following recent advances in research, however, there has been increased optimism that a prophylactic HIV vaccine is feasible. A consensus is forming among researchers to support a larger role for proof-of-concept efficacy clinical trials, conducted in parallel with invigorated basic research efforts and testing in animal models, to accelerate the discovery of key principles that will guide rational vaccine development.

Source: PubMed

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Keywords

effective vaccine
 
HIV vaccine
 
invigorated basic research efforts
 
key principles
 
larger role
 
proof-of-concept efficacy clinical trials
 
prophylactic HIV vaccine
 
researchers