Article

Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin.

School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.
Biotechnology Letters (impact factor: 1.68). 12/2010; 33(4):845-51. DOI:10.1007/s10529-010-0492-5
Source: PubMed

ABSTRACT Fibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of FGF2. Fibrin, HCF, FGF2-loaded fibrin, and FGF2-loaded HCF were implanted into full-thickness skin defects of mice. The neoepidermis thickness was significantly larger in the FGF2-loaded HCF group than in the other groups, except for the FGF2-loaded fibrin group. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in the FGF2-loaded HCF group. The enhanced skin regeneration accompanying the long-term delivery of FGF2 could be mediated, at least partially, by enhanced neovascularization and cell proliferation in the neodermis.

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Keywords

cell proliferation
 
enhanced skin regeneration accompanying
 
FGF2
 
FGF2-loaded fibrin
 
FGF2-loaded fibrin group
 
FGF2-loaded HCF
 
FGF2-loaded HCF group
 
Fibrin
 
Fibroblast growth factor 2
 
full-thickness skin defects
 
HCF
 
Heparin-conjugated fibrin
 
mice
 
neodermis
 
neoepidermis thickness
 
neovascularization
 
skin regeneration
 
Suprabasal cytokeratin differentiation