The Interplay Between Mitochondrial Dynamics and Mitophagy

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Antioxidants & Redox Signaling (Impact Factor: 7.41). 12/2010; 14(10):1939-51. DOI: 10.1089/ars.2010.3779
Source: PubMed


Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle of an individual mitochondrion reveals several points where fusion, fission, and mitophagy interact. Mitochondrial fission can produce an impaired daughter unit that will be targeted by the autophagic machinery. Mitochondrial fusion, on the other hand, may serve to dilute impaired respiratory components and thereby prevent their removal. The inverse dependency of fusion and mitophagy on membrane potential allows them to act as complementary rather than competitive fates of the daughter mitochondrion after a fission event. We discuss the interplay between mitochondrial dynamics and mitophagy in different tissues and in different disease models under both stress-induced and steady-state conditions.

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    • "Mitochondrial fission is essential for maintenance and repair as it facilitates the removal of damaged components by partitioning them to a daughter that can then be targeted for removal and degradation by mitophagy. However, excessive mitochondrial fission and mitophagy can compromise the metabolic capacity of a cell (Twig & Shirihai, 2011). "
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    • "Evidence was provided that changes in mitochondrial volume and/or (ultra) structure affect the kinetics of biochemical reactions and assembly of protein supercomplexes in the mitochondrial matrix (Lizana et al., 2008; Dieteren et al., 2011; Cogliati et al., 2013; Mannella et al., 2013). Although much progress was made during the last decade (e.g., Benard et al., 2007, 2013; Twig and Shirihai, 2011; Chan, 2012; Picard et al., 2013; Archer, 2013; Jose et al., 2013; Varikmaa et al., 2013; Rambold et al., 2015), it is still unclear how the various mitochondrial morphologies are mechanistically linked to mitochondrial functions. This might relate to the fact that various fission and fusion proteins also have roles outside of mitochondrial dynamics (e.g., Zorzano et al., 2010; Schrader et al., 2012). "
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    • "Mitochondria can change their shape, size and inner membrane structure in a dynamic fashion, and the mitochondria of a single cell do not function in isolation, but form a complex reticulum whose morphology undergoes continuous cycles of fusion and fission (Twig and Shirihai 2011). These opposing processes determine the architecture of the entire mitochondrial population for which a strict control of such events is essential for maintaining the metabolic function of mitochondria. "
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