Article

Certification of Vitamins and Carotenoids in SRM 3280 Multivitamin/Multielement Tablets

Analytical Chemistry Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, MS 8311, Gaithersburg, Maryland 20899-8392, United States.
Analytical Chemistry (Impact Factor: 5.83). 01/2011; 83(1):99-108. DOI: 10.1021/ac101953u
Source: PubMed

ABSTRACT A new multivitamin/multielement dietary supplement Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST), with certified and reference concentration values for 13 vitamins, 24 elements, and 2 carotenoids. The constituents have been measured by multiple analytical methods with data contributed by NIST and by collaborating laboratories. This effort included the first use of isotope dilution mass spectrometry for value assignment of both fat-soluble vitamins (FSVs) and water-soluble vitamins (WSVs). Excellent agreement was obtained among the methods, with relative expanded uncertainties for the certified concentration values typically ranging from <2% to 15% for vitamins.

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Jan 26, 2015