Article

A tale of tailless

Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, N.J., USA.
Developmental Neuroscience (Impact Factor: 2.45). 12/2010; 33(1):1-13. DOI: 10.1159/000321585
Source: PubMed

ABSTRACT Drosophila Tailless(Tll) and its vertebrate homologue Tlx are conserved orphan nuclear receptors specifically expressed in the eye and the forebrain. Tll and Tlx act primarily as transcriptional repressors through their interactions with transcriptional corepressors, Atrophin family proteins, and histone-tail/chromatin-modifying factors such as lysine-specific histone demethylase 1 and histone deacetylases. The functional importance of Tll and Tlx is made apparent by the recent discovery that they are expressed in neural stem cells (NSCs) and are required for self-renewal of these cells in both Drosophila and the mouse. This review provides a snapshot of current knowledge about Tll and Tlx and their transcriptional network, which maintains NSCs in developing and adult animals.

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    • "To identify the target gene in DAGL/inaE EP1101 responsible for lifespan extension and stress resistance, we performed a plasmid rescue and verified that a single EP-element insertion was present in the 5 0 un-translated region of DAGL/inaE. The EP-element insertion in DAGL/ inaE EP1101 disrupts the binding site of a transcriptional repressor Tailless (Gui et al., 2011). Semi-quantitative RT-PCR analysis revealed a threefold increase of DAGL/inaE mRNA levels in DAGL/inaE EP1101 compared with the control (Fig. 1C). "
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    • "TLX is an important regulator of stem cell fate in forebrain and retina (45), and defects in its expression are associated with behavioural abnormalities, blindness and glioblastoma as reviewed in (46). In addition to its role in development, TLX expression has been detected in neural stem cells in adult brain within cells lining the subventricular zone, and the subgranular layer of the dentate gyrus, as well as in striatum and cortex (47). "
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