Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vivo fertilization.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94115-0916, USA.
Fertility and sterility (Impact Factor: 4.59). 12/2010; 95(5):1816-9. DOI: 10.1016/j.fertnstert.2010.11.008
Source: PubMed


Bisphenol A (BPA) is an endocrine disruptor with estrogenic properties that can adversely affect meiotic spindle assemblies. Our data indicate that BPA exposure in female patients may interfere with oocyte quality during IVF, as suggested by the inverse association between serum unconjugated BPA concentration and normal fertilization.

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    • "A few human studies have analyzed the association between urinary BPA levels and oocyte yield, maturation, and fertilization (see Supplemental Material, Table S2). In a small prospective study of 58 infertile women and 37 male partners under going intracytoplasmic sperm injection or conventional IVF, Fujimoto et al. (2011) found an association between serum BPA concentrations and oocyte maturation only among Asian women, but an overall correlation between increasing serum concentrations and the develop mental potential of human oocytes. In two publications from the same prospective cohort of 84 women (Mok-Lin et al. 2010) and 174 women (Ehrlich et al. 2012a) undergoing IVF, increasing urinary BPA concentration was associated with decreased numbers of retrieved oocytes, mature oocytes (MII), and normally fertilized oocytes (2PN). "
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    ABSTRACT: Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action. Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction. Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development. Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant.
    Environmental Health Perspectives 06/2014; 122(8). DOI:10.1289/ehp.1307728 · 7.98 Impact Factor
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    • "BPA has been detected in the urine of men and women undergoing IVF/intracytoplasmic sperm injection (Mahalingaiah et al., 2008) and in follicular fluid at the time of egg retrieval in women undergoing IVF (Ikezuki et al., 2002), suggesting that human gametes may have BPA exposure during gametogenesis. There are preliminary studies evaluating the association of urinary BPA concentrations with IVF outcomes (Fujimoto et al., 2011). The biologically significant lowest dose of BPA exposure has not been as yet determined for the human gamete or embryo. "
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    ABSTRACT: There is a lack of data regarding potential exposure of gametes to bisphenol A during IVF. Detectable concentrations of bisphenol A were not found in commonly used IVF plastic culture dishes, suction tubing or growth media under normal-use conditions.
    Reproductive biomedicine online 09/2012; 25(6). DOI:10.1016/j.rbmo.2012.08.008 · 3.02 Impact Factor
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    • "As a result, 95% of adults who were tested had detectable levels of BPA in their urine (Calafat et al. 2008). Urine BPA levels of women undergoing infertility treatment are negatively correlated with the number and quality of eggs retrieved, and with serum E 2 levels (Mok- Lin et al. 2010; Fujimoto et al. 2011). "
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    ABSTRACT: There is a heightened interest and concern among scientists, clinicians and regulatory agencies as well as the general public, regarding the effects of environmental endocrine-disrupting chemicals (EDCs). In this review, we identify the main epigenetic mechanisms and describe key ovarian processes that are vulnerable to the epigenetic actions of EDCs. We also provide an overview of the human epidemiological evidence documenting the detrimental effects of several common environmental EDCs on female reproduction. We then focus on experimental evidence demonstrating the epigenetic effects of these EDCs in the ovary and female reproductive system, with an emphasis on methoxychlor, an organochlorine pesticide. We conclude the review by describing several critical issues in studying epigenetic effects of EDCs in the ovary, including transgenerational epigenetic effects.
    Reproduction in Domestic Animals 08/2012; 47 Suppl 4(s4):338-47. DOI:10.1111/j.1439-0531.2012.02096.x · 1.52 Impact Factor
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