Polyarteritis Nodosa in a Patient with Type 1 Autoimmune Hepatitis

Division of Gastroenterology and Hepatology and Rheumatology, 2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Southern medical journal (Impact Factor: 0.93). 01/2011; 104(1):49-52. DOI: 10.1097/SMJ.0b013e3181fd0be6
Source: PubMed


Polyarteritis nodosa is a systemic necrotizing vasculitis that affects small- and medium-sized arteries. Liver involvement in patients with polyarteritis nodosa has been described, and ranges from asymptomatic elevation of aminotransferases to hepatic aneurysm rupture. We describe the case of a patient with type 1 autoimmune hepatitis and compensated liver cirrhosis who developed classic polyarteritis nodosa, complicated with cytomegalovirus and repeated urinary tract infections. After a long bedridden hospitalization, the patient's condition was stabilized. She is currently in good health, with well-controlled blood pressure, and stable kidney and liver function. To our knowledge, this is the first case report in the literature with concurrent appearance of both diseases.

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Available from: Themistoklis Vassiliadis, Jul 07, 2015