Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

Cardiology Division, VA Medical Center, San Francisco, CA, USA.
Journal of Molecular and Cellular Cardiology (Impact Factor: 5.22). 11/2010; 51(4):518-28. DOI: 10.1016/j.yjmcc.2010.11.014
Source: PubMed

ABSTRACT Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."


Available from: Brian Jensen, Feb 18, 2015
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