Article

Regulation and biological function of the liver-specific miR-122.

Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Biochemical Society Transactions (impact factor: 3.71). 12/2010; 38(6):1553-7. DOI:10.1042/BST0381553 pp.1553-7
Source: PubMed

ABSTRACT miRNAs (microRNAs) are important regulators of gene expression. In higher eukaryotes, the tightly controlled expression of different miRNAs, each of which regulates multiple target mRNAs, is crucial for the maintenance of tissue type and the control of differentiation. miR-122 is a highly liver-specific miRNA that is important in hepatitis C virus infection, cholesterol metabolism and hepatocellular carcinoma. In the present review, we discuss the effects of miR-122 on liver physiology and pathology. Recent evidence of pathways involved in the regulation of miR-122 expression is also considered.

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Keywords

controlled expression
 
crucial
 
different miRNAs
 
hepatitis C virus infection
 
hepatocellular carcinoma
 
higher eukaryotes
 
liver physiology
 
liver-specific miRNA
 
miR-122 expression
 
miRNAs
 
Recent evidence
 
regulates multiple target mRNAs
 

Andrew P Lewis