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    • "However, it is difficult to draw conclusions as to whether these differences represent varying prevalence of distinct subtypes and tumour grade between distinct age-cohorts or whether they reflect other age related differences [20]. More recent work by Anders has suggested that the gene expression patterns uniting the younger cohort may relate to an enrichment of basal-like tumours in this patient group [21]. Our data, using two independently derived expression measures of CIN, suggest that a molecular feature of tumours from younger patients with ER negative breast cancers may reflect structural or numerical CIN. "
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    ABSTRACT: Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) is increasingly recognised as an important prognostic variable in solid tumours. In a breast cancer meta-analysis of 2423 patients we examine the relationship between clinicopathological parameters and two distinct chromosomal instability gene expression signatures in order to address whether younger age at diagnosis is associated with increased tumour genome instability. We find that CIN, assessed by the two independently derived CIN expression signatures, is significantly associated with increased tumour size, ER negative or HER2 positive disease, higher tumour grade and younger age at diagnosis in ER negative breast cancer. These data support the hypothesis that chromosomal instability may be a defining feature of breast cancer biology and clinical outcome.
    Oncotarget 06/2011; 2(7):529-37. DOI:10.18632/oncotarget.298 · 6.36 Impact Factor
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    ABSTRACT: Wir berichten über einen 71-jährigen Patienten mit einem zystischen Tumor im linken Oberbauch und lang andauernder Beschwerdesymptomatik in der Anamnese. Nach der klinischen und apparativen Diagnostik wird eine Laparotomie durchgeführt. Es erfolgt die komplette Exstirpation des Tumors mit Resektion der ersten Jejunumschlinge und Rekonstruktion der Darmpassage durch Handnahtanastomose. Der histologische Befund ergibt einen gastrointestinalen Stromatumor mit hohem Progressionsrisiko.
    Der Chirurg 04/2012; 83(4). DOI:10.1007/s00104-011-2250-1 · 0.57 Impact Factor
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    ABSTRACT: Triple-negative breast cancers (TNBC) have increased rates of pathologic complete response following neoadjuvant chemotherapy, yet have poorer prognosis compared with non-TNBC. Known as the triple-negative paradox, this highlights the need to dissect the biologic and clinical heterogeneity within TNBC. In the present issue, Keam and colleagues suggest two subgroups of TNBC exist based on the proliferation-related marker Ki-67, each with differential response and prognosis following neoadjuvant chemotherapy. To place results into context, we review several definitions available under the TNBC umbrella that may stratify TNBC into clinically relevant subgroups.
    Breast cancer research: BCR 04/2011; 13(2):105. DOI:10.1186/bcr2852 · 5.49 Impact Factor
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