Social cognition in psychosis: Multidimensional structure, clinical correlates, and relationship with functional outcome

Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, CA 90095-6968, USA.
Schizophrenia Research (Impact Factor: 3.92). 02/2011; 125(2-3):143-51. DOI: 10.1016/j.schres.2010.11.007
Source: PubMed


Social cognitive impairments are common, detectable across a wide range of tasks, and appear to play a key role in explaining poor outcome in schizophrenia and related psychotic disorders. However, little is known about the underlying factor structure of social cognition in people with psychotic disorders due to a lack of exploratory factor analyses using a relatively comprehensive social cognitive assessment battery. In a sample of 85 outpatients with psychosis, we examined the factor structure and clinical/functional correlates of eight indexes derived from five social cognition tasks that span the domains of emotional processing, social perception, attributional style, and Theory of Mind. Exploratory factor analysis revealed three factors with relatively low inter-correlations that explained a total of 54% of the variance: (1) Hostile attributional style, (2) Lower-level social cue detection, and (3) Higher-level inferential and regulatory processes. None of the factors showed significant correlations with negative symptoms. Factor 1 significantly correlated with clinical symptoms (positive, depression-anxiety, agitation) but not functional outcome, whereas Factors 2 and 3 significantly correlated with functional outcome (functional capacity and real-world social and work functioning) but not clinical symptoms. Furthermore, Factor 2 accounted for unique incremental variance in functional capacity, above and beyond non-social neurocognition (measured with MATRICS Consensus Cognitive Battery) and negative symptoms. Results suggest that multiple separable dimensions of social cognition can be identified in psychosis, and these factors show distinct patterns of correlation with clinical features and functional outcome.

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    • "It has been found in a number of studies that abnormalities in social perception are predictive of levels of everyday functioning in schizophrenia (Couture et al., 2006; Green et al., 2012; Hooker and Park, 2002; Mancuso et al., 2011; Rassovsky et al., 2011). Other work indicates that impairments in social functioning may precede and predict the development of schizophrenia in those at risk (Alderman et al., 2014; Cannon et al., 2008; Kwapil, 1998). "
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    ABSTRACT: Schizophrenia is associated with subtle abnormalities in day-to-day social behaviors, including a tendency in some patients to “keep their distance” from others in physical space. The neural basis of this abnormality, and related changes in social functioning, is unknown. Here we examined, in schizophrenic patients and healthy control subjects, the functioning of a parietal–frontal network involved in monitoring the space immediately surrounding the body (“personal space”). Using fMRI, we found that one region of this network, the dorsal intraparietal sulcus (DIPS), was hyper-responsive in schizophrenic patients to face stimuli appearing to move towards the subjects, intruding into personal space. This hyper-responsivity was predicted both by the size of personal space (which was abnormally elevated in the schizophrenia group) and the severity of negative symptoms. In contrast, in a second study, the activity of two lower-level visual areas that send information to DIPS (the fusiform face area and middle temporal area) was normal in schizophrenia. Together, these findings suggest that changes in parietal–frontal networks that support the sensory-guided initiation of behavior, including actions occurring in the space surrounding the body, contribute to social dysfunction and negative symptoms in schizophrenia.
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    • "Schizophrenia has recently been conceptualized as a neurodevelopmental disorder (Rapoport et al. 2012) with several symptom domains including cognitive deficits as essential factors correlated with functional outcome (Keefe 2008). Social cognition deficits present in schizophrenia are related to non-social cognition, but have a different neurobiological basis (Mancuso et al. 2011). Disorders of self-recognition and recognition of others may be a result of combination of different neuropathological and psychological factors with subsequent disruption of integration of the intero-self system with the external environment (Feinberg 2013). "
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    • "No statistical significance was showed for CYP-1020 as a procognitive enhancer. However, it seemed to be superior to risperidone in a measure of social cognition included in the MCCB battery (MSCEIT): an independent factor from the rest of cognitive domains (Mancuso et al., 2011). A new approach for the treatment of schizophrenia (ITI-007) was presented by Dr. Kimberly E. Vanover (Intra-celullar Therapies Inc., New York, USA). "
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    ABSTRACT: The 4th Schizophrenia International Research Society Conference was held in Florence, Italy, April 5–9, 2014 and this year had as its emphasis, “Fostering Collaboration in Schizophrenia Research”. Student travel awardees served as rapporteurs for each oral session, summarized the important contributions of each session and then each report was integrated into a final summary of data discussed at the entire conference by topic. It is hoped that by combining data from different presentations, patterns of interest will emerge and thus lead to new progress for the future.In addition, the following report provides an overview of the conference for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research.
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