Knutson KL. Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence. Best Pract Res Clin Endocrinol Metab 24, 731-743

Section of Pulmonary/Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Ave MC 6076, Chicago, IL 60622, USA.
Best Practice & Research: Clinical Endocrinology & Metabolism (Impact Factor: 4.6). 10/2010; 24(5):731-43. DOI: 10.1016/j.beem.2010.07.001
Source: PubMed


Laboratory studies have found that short-term sleep restriction is associated with impairments in glucose metabolism, appetite regulation and blood pressure regulation. This chapter reviews the epidemiologic evidence for an association between habitual sleep duration and quality and risk of cardiometabolic diseases including obesity, diabetes and hypertension. Multiple studies observed a cross-sectional association between short sleep duration (generally <6 h per night) and increased body mass index or obesity, prevalent diabetes and prevalent hypertension. Many studies also reported an association between self-reported long sleep duration (generally >8 h per night) and cardiometabolic disease. There have been a few prospective studies and several, but not all, have found an association between short sleep and incident diabetes, hypertension and markers of cardiovascular disease. Future prospective epidemiologic studies need to include objective measures of sleep, and intervention studies are needed in order to establish a causal link between impaired or insufficient sleep and cardiometabolic disease risk.

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Article: Knutson KL. Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence. Best Pract Res Clin Endocrinol Metab 24, 731-743

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    • "Studies frequently demonstrate that shorter (e.g., <6 hours/night) and longer (e.g., >8 hours/night) sleep durations, sleep quality complaints (e.g., frequently waking up, trouble initiating or maintaining sleep), and greater daytime sleepiness are associated with poorer mental and physical health (Cappuccio et al. 2010; Duncan et al. 2014; Empana et al. 2009; Holliday et al. 2013). Sleep is known to have a direct influence on health and to also operate through a combination of behavioral, metabolic, and hormonal factors to influence health and lifestyle behaviors (Grandner et al. 2010; Knutson 2010). For example, lack of sleep alters hormonal factors, which in turn lead to increased energy intake, preference for energy dense foods and poorer dietary quality (Chaput 2014). "

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    • "Night or rotating shifts and other irregular schedules affect sleep quality and quantity, with important physiological and behavioral consequences: fatigue, chronic health problems, altered metabolism, increased risk of injury, and disruption of family and social routines. Insufficient sleep has been correlated with changes in appetite/satiety regulation, metabolism , and insulin sensitivity, as well as a reduction in available energy to engage in physical activity (Knutson, 2010). Epidemiologically, shiftwork has been linked to metabolic syndrome (Tucker, Marquié, Folkard, Ansiau, & Esquirol, 2012) and short sleep with overweight status (Gildner, Liebert, Kowal, Chatterji, & Snodgrass, 2014). "
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