Article

Diversity of the early step of the futalosine pathway.

Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
Antimicrobial Agents and Chemotherapy (impact factor: 4.84). 02/2011; 55(2):913-6. DOI:10.1128/AAC.01362-10 pp.913-6
Source: PubMed

ABSTRACT We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs.

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Keywords

aminodeoxyfutalosine
 
attractive target
 
biosynthesis
 
dehypoxanthinyl futalosine
 
DHFL
 
futalosine
 
futalosine pathway
 
Helicobacter pylori
 
pylori drugs
 
specific anti-H
 
Thermus thermophilus