Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis

Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland.
Advances in Medical Sciences (Impact Factor: 1.11). 12/2010; 55(2):297-307. DOI: 10.2478/v10039-010-0048-x
Source: PubMed


A comparison of the clinical status and salivary MMP levels after SRP alone or with ozonotherapy in patients with aggressive and chronic periodontitis.
The study was performed in 52 generally healthy subjects with chronic or aggressive periodontitis. Group CP-S consisted of 12 patients with chronic periodontitis, who underwent scaling and root planing (SRP). In group CP-O there were 25 patients with chronic periodontitis who additionaly to SRP underwent ozonotherapy. The same therapy was performed in group AP, containing 15 patients with aggressive periodontitis. Plaque index, approximal plaque index, bleeding on probing, sulcus bleeding index, probing pocket depth and clinical attachment loss were measured at baseline, at two weeks and two months post-therapy. The levels of MMP-1, MMP-8 and MMP-9 were estimated in non-stimulated saliva with an ELISA method.
All the clinical parameters assessed in the study groups were reduced after treatment. SRP with additional ozonotherapy provided an increase in MMP levels in patients with chronic periodontitis and a reduction in MMP levels in patients with aggressive periodontitis.
SRP followed by ozonotherapy does not lead to further improvement in clinical periodontal parameters in patients with AP and CP.

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    • "Periodontitis is one of the major chronic inflammatory diseases associated with increased production of numerous proinflammatory cytokines, which lead to the destruction of periodontal tissues and ultimately loss of teeth. Tissue destruction in periodontitis results in breakdown of the collagen fibers of the periodontal ligament, resulting in the formation of a periodontal pocket between the gingiva and the tooth [2] [3]. There is emerging evidence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycemic control and the progression of vascular complications [6,7,11–16]. "
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