A randomized, controlled trial of computer-assisted cognitive remediation for schizophrenia

Université de Lyon, Lyon, F-69003, France.
Schizophrenia Research (Impact Factor: 3.92). 02/2011; 125(2-3):284-90. DOI: 10.1016/j.schres.2010.10.023
Source: PubMed


There is considerable interest in cognitive remediation for schizophrenia. Our study aimed to evaluate, in a large sample of patients with schizophrenia, the interest of a computer-assisted cognitive remediation program on cognitive performances of patients as well as in clinical and functional outcome.
Seventy-seven patients with remitted schizophrenia were randomly assigned to 14 2-hours individual sessions of computer-assisted cognitive remediation (n=39) or a control condition (n=38). Remediation was performed using RehaCom ® software. Four procedures were chosen to train four cognitive functions involved in different stages of the information processing: attention/concentration, working memory, logic, and executive functions. Primary outcomes were remediation exercise metrics, neuropsychological composites (episodic memory, working memory, attention, executive functioning, and processing speed), clinical and community functioning measures.
Cognitive performances concerning Attention/vigilance, verbal working memory and verbal learning memory and reasoning/problem solving improved significantly in the remediation condition when no difference was reported in the control condition between the 2 assessments. However, there were no significant benefits of cognitive remediation on non-verbal working memory and learning and speed of processing or functional outcome measures.
Cognitive remediation for people with schizophrenia was effective in improving performance, but the benefits of training did not generalize to functional outcome measures. Long term follow-up studies are needed to confirm the maintenance of such improvements.

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Available from: Jerome Brunelin, Feb 05, 2014
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    • "Many previous studies have reported that the AVE device can increase attentional skill and decrease impulsive behavior26,27,28). In addition, according to prior studies conducting cognitive performance and functional outcome with cognitive remediation therapy, motor skill training with the audio-visual stimulation improved performance, indicating that sensorimotor integration processing is a part of motor skill learning29, 30). Thus, we speculate that sleep induced with the device could reduce processing times via cognitive entrainment and increase motor skills. "
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    • "Nevertheless, the utilization of the computerized cognitive remediation training has not provided any evidence of the efficacy of the intervention in stable patients with schizophrenia [77, 78]. Although there has been a significant improvement of auditory processing speed, this effect did not lead to improved overall cognitive performance. "
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    BioMed Research International 09/2013; 2013:819587. DOI:10.1155/2013/819587 · 1.58 Impact Factor
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    • "A meta-analysis by Grynszpan et al. [21] confirms the moderate effect of computerized training in schizophrenia. Especially in working memory, improvements are reported after a combination of work-therapy and neurocognitive enhancement therapy [22, 23], as well as after computer-assisted cognitive remediation [24, 25]. A recent meta-analysis composing 40 studies on the efficacy of cognitive remediation in schizophrenia [26] confirms that patients profit from this kind of intervention. "
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