Comprehensive meta-analysis of the risk of suicide in eating disorders

Centro Medico Genneruxi, Via Costantinopoli 42, Cagliari, Italy.
Acta Psychiatrica Scandinavica (Impact Factor: 5.61). 11/2010; 124(1):6-17. DOI: 10.1111/j.1600-0447.2010.01641.x
Source: PubMed


Past meta-analyses on suicide in eating disorders included few available studies.
PubMed/Medline search for papers including sample n ≥40 and follow-up ≥5 years: 40 studies on anorexia nervosa (AN), 16 studies on bulimia nervosa (BN), and three studies on binge eating disorder (BED) were included.
Of 16,342 patients with AN, 245 suicides occurred over a mean follow-up of 11.1 years (suicide rate=0.124 per 100 person-years). Standardized mortality ratio (SMR) was 31.0 (Poisson 95% CI=21.0-44.0); a clear decrease in suicide risk over time was observed in recent decades. Of 1768 patients with BN, four suicides occurred over a mean follow-up of 7.5 years (suicide rate=0.030 per 100 person-years): SMR was 7.5 (1.6-11.6). No suicide occurred among 246 patients with BED (mean follow-up=5.3 years).
AN and BN share many risk factors for suicide: the factors causing lower suicide rates per person-year in BN compared to AN should be investigated.

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    • "If we consider that early detection of ED is associated with better treatment outcomes (van Son, van Hoek van Furth, Donker, & Hoek, 2010), and a decrease in suicide rates (Preti et al., 2011), it is of great importance that scientific research and clinical training consider specific gender aspects in the assessment and treatment of ED and body dissatisfaction in men. "
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    ABSTRACT: Eating disorders (ED) are usually considered a feminine pathology (Darcy & Lin, 2012; Striegel-Moore & Bulik, 2007), where the prevalence of male cases is considerably lower (Hoek, 2006). However, in many cases, men with ED go undetected because their problem is unknown and assessment is not always properly performed.
    International journal of emergency mental health 07/2015; 17(2):570-572. DOI:10.4172/1522-4821.1000220
    • "This behavior is often accompanied by an irrational fear of weight gain, excessive exercise, distorted body image and menstrual dysfunction in women (Yilmaz et al. 2014). Anorexia nervosa prevalence is estimated to be between 0.3 and 0.9%, around 90% of cases are female (Yilmaz et al. 2014), and it carries the highest mortality rate of any psychiatric illness with suicide being a common cause of death (Arcelus et al. 2011; Chesney et al. 2014; Franko et al. 2013; Preti et al. 2010; Smink et al. 2013; Sullivan 1995). Bulimia nervosa is characterized by recurrent episodes of binge eating (i.e. "
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    ABSTRACT: Eating disorders are complex brain disorders that afflict millions of individuals worldwide. The etiology of these diseases is not fully understood, but a growing body of literature suggests that stress and anxiety may play a critical role in their development. As our understanding of the genetic and environmental factors that contribute to disease in clinical populations like anorexia nervosa, bulimia nervosa, and binge eating disorder continue to grow, neuroscientists are using animal models to understand the neurobiology of stress and feeding. We hypothesize that eating disorder clinical phenotypes may result from stress-induced maladaptive alterations in neural circuits that regulate feeding, and that these circuits can be neurochemically isolated using animal model of eating disorders.
    Genes Brain and Behavior 10/2014; 14(1). DOI:10.1111/gbb.12185 · 3.66 Impact Factor
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    • "A recent meta-analysis showed mortality rates to be twice as high in those with BN and EDNOS and close to six times higher in people with AN when compared to expected population mortality rates [6]. Suicide contributes significantly to these high mortality rates, with rates of suicide elevated among those with eating disorders [7-9]. Comorbidity with depression, anxiety and substance use disorders is common [10-13], adding significantly to the burden. "
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    ABSTRACT: Eating disorders often develop during adolescence and young adulthood, and are associated with significant psychological and physical burden. Identifying evidence-based interventions is critical and there is need to take stock of the extant literature, to inform clinical practice regarding well-researched interventions and to direct future research agendas by identifying gaps in the evidence base.
    International Journal of Eating Disorders 02/2014; 2(1):5. DOI:10.1186/2050-2974-2-5 · 3.13 Impact Factor
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