Article

Building Addressable Libraries: The Use of "Safety-Catch" Linkers on Microelectrode Arrays.

Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States, and CustomArray Inc., 6500 Harbor Heights Parkway, Suite 202, Mukilteo, Washington 98275, United States.
Journal of the American Chemical Society (impact factor: 9.91). 11/2010; DOI:10.1021/ja109253t
Source: PubMed

ABSTRACT A "safety-catch" linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.

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Keywords

ester
 
linker strategy
 
linkers
 
microelectrode array
 
microelectrodes
 
protected amine
 

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