Article

Immunoregulation of GVHD by triggering the innate immune system with CpG.

Department of Bone Marrow Transplantation and Cancer Immunotherapy, Cell Therapy and Transplantation Research Laboratory, Hadassah University Hospital, Jerusalem, Israel.
Expert Review of Hematology (impact factor: 1.16). 08/2009; 2(4):443-53. DOI:10.1586/ehm.09.29 pp.443-53
Source: PubMed

ABSTRACT Stimulation of Toll-like receptors by oligodeoxynucleotide sequences containing a CpG motif provides signals capable of triggering the innate and adaptive immune systems, thereby leading either to stimulation or suppression of immunoreactivities. Similar immunoregulatory capabilities are necessary for achieving the fine balance between engraftment and graft-versus-host disease required in the setup of allogeneic cell therapy. Ligation of CpG to its Toll-like receptors can be accomplished by treatment of the host or pretransplant treatment of the donor in vivo. These different strategies are presented in this review, which summarizes the attempts to maximize beneficial alloreactivity against malignant or other undesirable host cells, while controlling graft-versus-host disease.

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Keywords

adaptive immune systems
 
allogeneic cell therapy
 
CpG
 
CpG motif
 
engraftment
 
graft-versus-host disease
 
immunoreactivities
 
oligodeoxynucleotide sequences
 
pretransplant treatment
 
signals capable
 
Similar immunoregulatory capabilities
 
Stimulation
 
summarizes
 
Toll-like receptors
 
undesirable host cells
 
vivo
 

Shoshana Morecki