Start » Publications

Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator.

Evan W Miller, Nicolas Taulet, Carl S Onak, Elizabeth J New, Julie K Lanselle, Gillian S Smelick, Christopher J Chang

Department of Chemistry and the Howard Hughes Medical Institute, University of California, Berkeley, California 94720, United States and Department of Immunology and Microbial Science and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, United States.

Journal Article: Journal of the American Chemical Society (impact factor: 8.58). 11/2010; DOI: 10.1021/ja107783j

Abstract

Hydrogen peroxide (H(2)O(2)) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H(2)O(2) on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H(2)O(2) as well as remote control of cell behavior via H(2)O(2)-mediated pathways.

Source: PubMed

Comments on this publication

ResearchGate members can add comments. Sign up now and post your comment!

Similar publications

Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Science & Research Jobs

View jobs

Keywords

chemical method
 
cofilin-actin rod formation
 
dissecting biological roles
 
H(2)O(2)-mediated pathways
 
new small-molecule probe
 
optical regulation
 
potential opportunities
 
remote control