We report a case of primary bone lymphoma (PBL) in a 15-year-old girl assessed by MR imaging with diffusion-weighted imaging (DWI). DWI has been shown to help characterize the cellularity of solid tumors and this case correlates well with previous data.
"Accordingly to its relatively high cellularity , primary bone lymphomas exhibit restricted diffusion with low apparent diffusion co-efficiency value on diffusion-weighted imaging . An increased post-treatment apparent diffusion co-efficiency value correlates with higher tumour necrosis  and is usually consistent with decreased 18 fluorodeoxyglycose ( 18 FDG) uptake on 18 FDG-PET scan , suggesting tumour response (see below). "
Cancer Treatment Reviews 02/2015; 41(3). DOI:10.1016/j.ctrv.2015.02.001 · 7.59 Impact Factor
"Ewing sarcoma is a member of small round blue cell tumors, undifferentiated aggressive embryonal tumors, which have similar histological features. Our findings were similar with previous studies. Small round blue cell tumors should be in the differential diagnosis of the tumors with very low ADC values. "
[Show abstract][Hide abstract] ABSTRACT: The study aims to determine whether apparent diffusion coefficient (ADC) can help differentiate benign and malignant bone tumors.
From January 2012 to February 2013, we prospectively included 26 patients. Of these 15 patients were male and 11 were female; ranging in age from 8 to 76 years (mean age, 34.5 years). Diffusion-weighted magnetic resonance (MR) imaging was obtained with a single-shot echo-planar imaging sequence using a 1.5T MR scanner. We grouped malignant lesions as primary, secondary, and primary tumor with chondroid matrix. The minimum ADC was measured in the tumors and mean minimum ADC values were selected for statistical analysis. ADC values were compared between malignant and benign tumors using the Mann-Whitney U-test and receiver operating curve analysis were done to determine optimal cut-off values.
The mean ADC values from the area with lowest ADC values of benign and malignant tumors were 1.99 ± 0.57 × 10(-3) mm(2)/s and 1.02 ± 1.0 × 10(-3) mm(2)/s, respectively. The mean minimum ADC values of benign and malignant tumors were statistically different (P = 0.029). With cut-off value of 1.37 (10(-3) mm(2)/s), sensitivity was 77.8% and specificity was 82.4%, for distinguishing benign and malignant lesion. Benign and secondary malignant tumors showed statistically significant difference (P = 0.002). There was some overlap in ADC values between benign and malignant tumors. The mean minimum ADC values of benign and malignant chondroid tumors were high. Giant cell tumor, non-ossifying fibroma and fibrous dysplasia showed lower ADC values.
Although there is some overlap, ADC values of benign and malignant bone tumors seem to be different. Further studies with larger patient groups are needed to find an optimal cut-off ADC value.
Journal of Clinical Imaging Science 12/2013; 3(1):63. DOI:10.4103/2156-7514.124094
[Show abstract][Hide abstract] ABSTRACT: We report two children with lymphoma of bone centered in the distal femoral epiphysis who presented with knee pain. Radiographs, magnetic resonance imaging (MRI) and computed tomography (CT) were performed on both patients prior to biopsy. Following biopsy, both patients had fluorodeoxyglucose ((18) F-FDG) positron emission tomography/CT (PET/CT) and whole-body technetium-99m (Tc-99m) scintigraphy performed for staging. One patient met the criteria for primary lymphoma of bone. One patient did not meet the criteria for primary lymphoma of bone because of PET uptake in a popliteal, external iliac and possibly lower abdominal node. Both patients responded well to chemotherapy and are disease free more than 7 years after diagnosis. While an epiphyseal presentation of lymphoma of bone is rare, the efficacy of treatment and the compromised outcome associated with diffuse spread of the disease make early recognition by clinicians important. We present these two cases to increase awareness of the disease and to have clinicians consider it in the differential diagnosis of adolescent epiphyseal lesions.
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