Article

Can Antitumor Immunity Help to Explain “Oncogene Addiction”?

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cancer cell (Impact Factor: 23.89). 11/2010; 18(5):403-5. DOI: 10.1016/j.ccr.2010.11.002
Source: PubMed

ABSTRACT "Oncogene addiction" refers to the process of tumor cell death that can occur after inactivation of a single oncogene. In this issue of Cancer Cell, Rakhra et al. argue that complete tumor clearance after molecular targeted therapies requires a functioning immune system, pointing the way toward radically new combination therapies.

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Available from: Nicholas P Restifo, Aug 04, 2015
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