The aqueous extract of Terminalia superba (Combretaceae) prevents glucose-induced hypertension in rats

Laboratoire de Physiologie Animale, Faculté des Sciences, Université de Yaoundé I, PO Box 812, Yaounde, Cameroon.
Journal of ethnopharmacology (Impact Factor: 3). 11/2010; 133(2):828-33. DOI: 10.1016/j.jep.2010.11.016
Source: PubMed


The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. The aim of this study was to investigate the hypotensive and the antihypertensive effects of the aqueous extract of the stem bark of Terminalia superba.
Hypertension was obtained in rats by oral administration of 10% D-glucose for 3 weeks. The acute effects of Terminalia superba were studied on blood pressure (BP) and heart rate (HR) after intravenous administration in normotensive rats (NTR) and glucose hypertensive rats (GHR). The antihypertensive effects were studied after oral administration of the extract (50 and 100 mg/kg/day) or nifedipine (10 mg/kg/day) for 3 weeks. At the end of the experiment, BP and HR were measured and reduced glutathione (GSH), malondialdehyde (MDA) and superoxide dismutase (SOD) activity levels were measured in heart, aorta, liver and kidney.
Intravenous administration of the aqueous extract of Terminalia superba induced a significant hypotensive response without any change in HR. The hypotensive effect of the extract was unaffected by atropine or propranolol but decreased by reserpine (5 mg/kg) and yohimbine (0.1 mg/kg). In addition, the oral administration of the extract significantly prevented the rise in BP in glucose-hypertensive rats. Finally, the treatment with plant extract significantly blunted the decrease in GSH and the increase in MDA levels associated with hypertension, and significantly prevents the increase in aortic SOD activity.
The present study demonstrates that the aqueous extract of the stem bark of Terminalia superba exhibits hypotensive and anti-hypertensive properties that are, at least in part, related to a withdrawal of sympathetic tone and to an improvement of the antioxidant status, respectively. Overall data validate the use of Terminalia superba as antihypertensive therapy in traditional medicine.

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    • "Le suc des feuilles soigne la conjonctivite [18]. Cette plante est aussi utilisée dans le traitement de l'hypertension artérielle [21]. "
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    ABSTRACT: Terminalia superba Engl. et Diels (Combretaceae) est une plante largement répartie en Afrique. Elle est beaucoup employée en pharmacopée indigène. Le présent travail a pour objectif de réaliser une synthèse bibliographique et une analyse des résultats de recherche portant sur la composition phytochimique ainsi que les propriétés biologiques et pharmacologiques de T. superba. Ce travail a permis de noter que cette plante est riche ; acide gallique et gallate de méthyle, époxylignanes, triterpènes glucosides, acide ellagique. Ces groupent chimiques peuvent seuls ou dans une possible synergie d'action, être responsables d'activités biologiques et pharmacologiques notamment des activités anti-diabétiques, anti-parasitaires, anti-microbiennes, anti-hypertensives, anti-oxydantes, anti-ulcéreuses, anti-diarrhéiques et analgésiques. En conclusion, par ses vertus, T. superba est une potentielle source de recettes médicinales.
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    • "í µí»¼-and í µí»½-amyrin, sitosterol, and a mixture of glycosidic flavonoids in the ethanolic extract of the leaves of T. fagifolia and investigated the antioxidant activity of fractions of this extract. Literature about the botanical family Combretaceae reports the detection of a variety of biological activities and a ubiquitous antioxidant property in genuses Terminalia and Combretum [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21]. Investigations with Terminalia arjuna (Roxb.) "
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    ABSTRACT: The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have been evaluated. TFEE presented low acute toxicity, antioxidant, and antiulcerogenic activity against ethanol-induced ulcers, which was partially blocked by pretreatment with L-NAME and indomethacin. It reduced the total acidity and raised the pH of gastric secretion. Additionally, TFEE delayed gastric emptying and slightly inhibited the small intestinal transit and also presented a weakly antidiarrheal activity. The antiulcerogenic and antioxidant activity were also detected in TFAqF and TFHAF but not in TFHEXF. The antisecretory and gastroprotective activity of TFEE partially involve the nitric oxide and prostaglandin participation. Nevertheless, TFEE, TFAqF, and TFHAF drastically reduced the mucus layer adhered to the gastric wall of rats treated with ethanol or indomethacin. Complementary studies are required in order to clarify the paradox of the presence of a gastroprotector activity in this plant that, at the same time, reduces the mucus layer adhered to the gastric wall.
    BioMed Research International 05/2014; 2014(2):261745. DOI:10.1155/2014/261745 · 1.58 Impact Factor
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    • "Previous animal studies investigated the cardiometabolic properties of Terminalia superba. The stem bark methanol/methylene chloride extract was reported to have anti-diabetic activity (Kamtchouing et al., 2005; Patel et al., 2012) The aqueous extract revealed hypoglycemic and hypolipidemic activity (Momo et al., 2009) and prevented the rise in blood pressure associated to the chronic intake of glucose (Tom et al., 2011). In addition, the methylene chloride extract of stem bark of Terminalia superba (TMSE) was shown to exhibit a potent vasorelaxant activity in aortic isolated rings from normotensive rats (Tom et al., 2010). "
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    ABSTRACT: The stem bark of Terminalia superba (TS) is widely used as a decoction by Cameroonian folk medicine for the treatment of hypertension. The aim of the present study was to evaluate the effect of a chronic treatment with a TS extract on spontaneously hypertensive rats (SHR) with respect to efficacy, biochemical mechanisms and safety. Eleven-week-old SHR and normotensive Wistar Kyoto rats (WKY) were daily treated by gavage with a methylene chloride extract of stem bark of Terminalia superba (TMSE, 150mg/kg) or with the vehicle for 5 weeks. Systolic blood pressure (SBP) was measured weekly using the tail-cuff method. At the end of the treatment period, vascular function was assessed on isolated thoracic rings, urinary 8-iso-PGF2α levels were measured and cytochrome P-450 3A (CYP 3A) activity was evaluated in liver microsomes. TMSE reduced SBP (P<0.001) in SHR but not in WKY rats. In SHR, the vasorelaxant response to acetylcholine was significantly improved by TMSE as a result of increased nitric oxide synthase (NO) activity and decreased superoxide anion production. In addition, TMSE reduced the vasoconstrictive effect of phenylephrine and improved the sensitivity of smooth muscle cells to NO. TMSE dramatically decreased 8-iso-PGF2α levels in SHR. By contrast, TMSE did not affect all these parameters in WKY rats. Neither diuresis nor the hepatic CYP 3A activity was modified in both animal groups. This study demonstrated that Terminalia superba has a potent antihypertensive activity in SHR which is partly due to endothelium-dependent and endothelium-independent effects as well as decreased oxidative stress. The data also provide evidence for the lack of herb-drug interaction through hepatic CYP 3A.
    Journal of ethnopharmacology 11/2013; 151(1). DOI:10.1016/j.jep.2013.10.057 · 3.00 Impact Factor
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