Is Diabetes Mellitus a Continuous Spectrum?

Department of Medicine, DVA Puget Sound Health Care System, Seattle, WA 98108, USA.
Clinical Chemistry (Impact Factor: 7.77). 11/2010; 57(2):158-61. DOI: 10.1373/clinchem.2010.148270
Source: PubMed

ABSTRACT Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease.
The current diabetes classification scheme needs to be reevaluated because of the accumulating evidence of immune system involvement in the pathophysiology of type 2 diabetes.
There are similarities and differences between type 1 and type 2 diabetes with regard to pathogenesis, pathophysiology, and genetics. We propose a resolution to the dilemma of the current classification scheme.

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