Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: The TERRACE study

University Medical Center Utrecht, Utrecht, The Netherlands.
Gastrointestinal endoscopy (Impact Factor: 5.37). 11/2010; 73(3):480-9. DOI: 10.1016/j.gie.2010.09.004
Source: PubMed


Although colonoscopy is currently the optimal method for detecting colorectal polyps, some are missed. The Third Eye Retroscope provides an additional retrograde view that may detect polyps behind folds.
To determine whether the addition of the Third Eye Retroscope to colonoscopy improves the adenoma detection rate.
Prospective, multicenter, randomized, controlled trial.
Nine European and U.S. centers.
Of 448 enrolled subjects, 395 had data for 2 procedures.
Subjects underwent same-day tandem examinations with standard colonoscopy (SC) and Third Eye colonoscopy (TEC). Subjects were randomized to SC followed by TEC or TEC followed by SC.
Detection rates for all polyps and adenomas with each method.
In the per-protocol population, 173 subjects underwent SC and then TEC, and TEC yielded 78 additional polyps (48.8%), including 49 adenomas (45.8%). In 176 subjects undergoing TEC and then SC, SC yielded 31 additional polyps (19.0%), including 26 adenomas (22.6%). Net additional detection rates with TEC were 29.8% for polyps and 23.2% for adenomas. The relative risk of missing with SC compared with TEC was 2.56 for polyps (P < .001) and 1.92 for adenomas (P = .029). Mean withdrawal times for SC and TEC were 7.58 and 9.52 minutes, respectively (P < .001). The median difference in withdrawal times was 1 minute (P < .001). The mean total procedure times for SC and TEC were 16.97 and 20.87 minutes, respectively (P < .001).
Despite randomization and a large cohort, there was disparity in polyp prevalence between the 2 groups of subjects.
The Third Eye Retroscope increases adenoma detection rate by visualizing areas behind folds. (Clinical trial registration number: NCT01044732.).

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    • "Three studies involving over 900 patients examined the TER in regard to both polyp and adenoma detection rates. 84-86(See table 2.) All of the studies showed an increase in the PDR and ADR and the results were similar among the three groups with respect to the right colon. An interesting and unexpected finding was that a high number of additional polyps and adenomas detected on the left side with the third eye retroscope. "
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