Antioxidant Vitamins Intake, Ataxia Telangiectasia Mutated (ATM) Genetic Polymorphisms, and Breast Cancer Risk

Kangwon National University School of Medicine, Gangwon-Do, Korea.
Nutrition and Cancer (Impact Factor: 2.32). 11/2010; 62(8):1087-94. DOI: 10.1080/01635581.2010.492088
Source: PubMed


Ataxia telangiectasia mutated (ATM) cells exist under a constant state of oxidative stress with high levels of reactive oxygen species, which are removed by cellular antioxidant vitamins. We investigated the independent and combined effect of antioxidant vitamins intake and the ATM genotype or diplotype on the breast cancer risk. Analyses included 323 cases and age-matched controls who participated in the Korean Breast Cancer Study during 2001-2003 with complete dietary information. The vitamin A (P < 0.01) and α-tocopherol (P < 0.01) were associated with lower breast cancer risk as well as some water-soluble vitamins including vitamin B(2) (P = 0.01), vitamin C (P < 0.01), and folic acid (P = 0.02) intake. No five single nucleotide polymorphisms (ATM-5144A > T (rs228589), IVS21 + 1049T > C (rs664677), IVS33-55T > C (rs664982), IVS34+60G > A (rs664143), and 3393T > G (rs4585)) studied showed significant differences in their allele frequencies between the cases and controls. On the other hand, compared with the diploid of ATTGT/ATTGT, as the number of ATTGT haplotype decreased, the risk of breast cancer increased (P = 0.04). The association between ATM diplotype and the breast cancer risk was predominantly among women with low intake of antioxidant vitamins including vitamin A, vitamin C, and folic acid. This study suggested that some antioxidant vitamins intake may modify the effect of ATM diplotype on the breast cancer risk among Korean women.

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    • "Study or subgroup Graham, 1991 Freudenheim, 1996 Thorand, 1998 Potischman, 1999 Ronco, 1999 Negri, 2000 Levi, 2001 Shrubsole, 2001 Sharp, 2002 Adzersen, 2003 Zhu, 2003 Chen, 2005 Lajous, 2006 Suzuki, 2008 Gao, 2009 Ma, 2009b Ma, 2009a Beasley, 2010 Lee, 2010 Yang, 2010 Marian, 2011 Zhang, 2011 Lee, 2012 Yang, 2013 Gong, 2014 "
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