Delay in Diagnosis and Treatment of Squamous Cell Carcinoma of the Skin

Istituto Dermopatico dell'Immacolata, Rome, Italy.
Acta Dermato-Venereologica (Impact Factor: 3.03). 11/2010; 90(6):595-601. DOI: 10.2340/00015555-0966
Source: PubMed


Advanced squamous cell carcinomas (SCC) of the skin can cause significant tissue destruction and may metastasize. Understanding the determinants of patient delay could help prevent advanced presentation. The purpose of the present study was to examine patient- and healthcare-related factors associated with delay before the detection and treatment of SCC. A sample of 308 patients with SCC treated at a dermatological referral centre in Italy were interviewed. Clinical data were obtained from the medical records. The highest quartile patients reported > 9 months delay between noticing the lesion and the first medical visit (defined as long patient delay). Multivariate analysis showed that SCC arising on pre-existing chronic lesions were associated with long patient delay (odds ratio = 3.17; 95% confidence interval 1.1-9.3). Controlling for confounders, the first physician's advice to remove the lesion immediately was associated with a shorter treatment delay (p < 0.001). In conclusion, our work emphasizes the importance of seeing a doctor about any change in a pre-existing lesion, particularly in light of the fact that SCC on chronic lesions are at greater risk of metastasis and recurrence.


Available from: Alessio Caggiati
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    • "A telephone survey in recently treated Squamous Cell Carcinoma patients in Italy also found skin cancer knowledge to be low [24]. We found no significant difference in knowledge from diagnosis to 8 weeks post treatment. "
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    • "To prove the effect of preoperative biopsy on recurrence of BCC and SCC, the recurrence rates of BCC or SCC with and without biopsy were compared, respectively, using a logistic regression analysis, controlling for confounding factors including age, sex, and tumor size [2]. Furthermore, to confirm the relationship between the interval from biopsy to operation and postoperative recurrence, a logistic regression analysis was performed among the biopsy groups. "
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