D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain

Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507-1912, United States.
Brain research bulletin (Impact Factor: 2.72). 11/2010; 84(1):12-6. DOI: 10.1016/j.brainresbull.2010.10.010
Source: PubMed


The Balb/c mouse strain shows quantitative deficits of sociability and is behaviorally-hypersensitive to MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist. D-Serine (560mg/kg, intraperitoneally), a full agonist for the obligatory glycine co-agonist binding site on the NMDA receptor, increased the amount of time Balb/c mice spend in a compartment containing the enclosed social stimulus mouse and the amount of time Balb/c mice spend exploring (sniffing) an inverted cup containing the enclosed social stimulus mouse in a standard sociability apparatus. These effects of D-serine on the impaired sociability of the Balb/c mouse strain were not due to a "nonspecific" effect on locomotor activity; importantly, the locomotor activity of the Balb/c mouse strain decreases in the presence of an enclosed or freely-moving social stimulus mouse. The data suggest that dimensions of the impaired sociability of the Balb/c mouse strain may be improved by targeted NMDA receptor agonist interventions.

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    • "Because the Balb/c mouse is behaviorally hypersensitive to MK-801, D-cycloserine and D-serine, a partial and full glycine B agonist acting at the NMDA receptor, respectively, were investigated for their ability to improve sociability in this mouse strain. The data showed that these targeted NMDA receptor agonist interventions improved several quantitative measures of sociability in 4-and 8-week-old Balb/c mice (Deutsch et al., 2011a, 2012; Jacome et al., 2011a). Further, the C57Bl/6 strain of mouse spent more time exploring D-cycloserinetreated Balb/c mice than they did exploring vehicle-treated Balb/c mice, suggesting that D-cycloserine " normalized " social signals emitted by the Balb/c strain (Benson et al., 2013). "
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    • "The laboratory adopted an established mouse behavioral procedure for the quantitative assessment of sociability (Brodkin, 2007; Burket et al., 2013, 2010; Crawley, 2007, 2004; Deutsch et al., 2012, 2011; Jacome et al., 2011a; Sankoorikal et al., 2006). Briefly, in the first session, a test mouse is placed in the middle compartment and allowed to acclimate to the sociability apparatus for 5 min. "
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    Brain research bulletin 11/2013; 100. DOI:10.1016/j.brainresbull.2013.11.005 · 2.72 Impact Factor
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    • "BALB/c mice also exhibit low sociability, exaggerated aggression, enlarged brain mass, low serotonin levels (Brodkin, 2007) and decreased passive social behavior (Fairless, Katz, 2013), suggesting them as a genetic model of ASD-related states. Systemic treatment of BALB/c mice with MK-801, an allosteric inhibitor of the glutamatergic (NMDA) receptors, elicits stereotypic circling behavior (Burket et al. , 2010), whereas D-serine, a NMDA receptor agonist, increases sociability (Jacome et al. , 2011). Together, this suggests the involvement of glutamatergic pathways in the pathogenesis of locomotor stereotypies and social impairment in the BALB/c mouse model of ASD-like behavior. "
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