Article

Previous preeclampsia and risks of adverse outcomes in subsequent nonpreeclamptic pregnancies.

Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Sweden.
American journal of obstetrics and gynecology (impact factor: 3.28). 11/2010; 204(2):148.e1-6. DOI:10.1016/j.ajog.2010.09.003 pp.148.e1-6
Source: PubMed

ABSTRACT We hypothesized that preeclampsia partly shares pathophysiology with stillbirth, placental abruption, spontaneous preterm birth, and giving birth to a small-for-gestational-age infant, and that women who develop preeclampsia in the first pregnancy may have increased risks of the other outcomes in the second pregnancy, even in the absence of preeclampsia.
In a nationwide Swedish cohort (n = 354,676) we estimated risks of adverse outcomes in the second pregnancy related to preterm (< 37 weeks) and term (≥ 37 weeks) preeclampsia in the first pregnancy, using women without preeclampsia in the first pregnancy as reference.
Women with prior preterm preeclampsia had, in second pregnancy, more than doubled risks of stillbirth, placental abruption, and preterm births, and an even greater risk of giving birth to a small-for-gestational-age infant.
Women with previous preterm preeclampsia have increased risks of adverse pregnancy outcomes in a second pregnancy despite the absence of preeclampsia.

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Keywords

adverse outcomes
 
adverse pregnancy outcomes
 
first pregnancy
 
nationwide Swedish cohort
 
placental abruption
 
preeclampsia
 
preterm
 
preterm births
 
previous preterm preeclampsia
 
prior preterm preeclampsia
 
risks
 
second pregnancy
 
small-for-gestational-age infant
 
spontaneous preterm birth
 
stillbirth
 
Women
 

Anna-Karin Wikström