Article

Prevalence of parietal cell antibodies in a large cohort of patients with autoimmune thyroiditis.

Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Siena, Italy.
Thyroid: official journal of the American Thyroid Association (impact factor: 2.6). 11/2010; 20(12):1385-9. DOI:10.1089/thy.2010.0041
Source: PubMed

ABSTRACT Autoimmune thyroiditis (AIT) may be associated with other organ-specific autoimmune disorders, including autoimmune gastritis, but the prevalence of this association is not entirely quantified. The aim of this study was to investigate the prevalence of parietal cell antibodies (PCA) in a large cohort of consecutive patients with AIT.
We retrospectively studied 2016 consecutive women and 258 men with AIT seen at our referral center in the period from 2004 to 2008. All patients were screened for the presence of PCA in the serum.
The prevalence of serum PCA in female patients was 29.7% and progressively increased from 13% in the first-second decade of life to peak at 42% in the ninth decade. During follow up, 21.1% of the PCA-positive patients converted to PCA-negative status. Mean (±standard deviation) basal PCA levels in this group were significantly lower (32 ± 28 U/mL) compared with those remaining PCA positive (129 ± 200 U/mL). A similar prevalence (29.8%) with a similar age-dependency was found in male patients.
In conclusion, our study demonstrates a high, age-dependent prevalence of PCA in an unselected large population of patients with AIT.

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Keywords

age-dependent prevalence
 
autoimmune gastritis
 
Autoimmune thyroiditis
 
consecutive patients
 
female patients
 
first-second decade
 
large cohort
 
male patients
 
ninth decade
 
organ-specific autoimmune disorders
 
parietal cell antibodies
 
PCA-negative status
 
PCA-positive patients
 
prevalence
 
referral center
 
remaining PCA positive
 
similar age-dependency
 
similar prevalence
 
unselected large population
 
±standard deviation
 

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