Article

Prevalence of a streptococcal inhibitor of a complement-mediated cell lysis-like gene (sicG) in Streptococcus dysgalactiae subsp. equisimilis.

Department of Bacteriology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Current Microbiology (impact factor: 1.82). 11/2010; 62(3):884-7. DOI:10.1007/s00284-010-9798-8 pp.884-7
Source: PubMed

ABSTRACT Streptococcus dysgalactiae subsp. equisimilis isolates (n = 110) were analyzed by PCR to determine whether the gene encoding SICG, a homolog of Streptococcus pyogenes SIC, was present. Nineteen strains (17%) had this gene of which 11 (55%) were isolated from patients with invasive disease. All 19 strains possessed group G carbohydrate. Molecular characterization of emm type revealed that the majority of emm sequences were stG643 and stG2078. Only the N-terminal sequence of SICG was similar to that of SIC in S. pyogenes. Although we found no significant relationship between pathogenic severity and sicG possession, further investigation into the mechanism of SICG may elucidate the virulence in S. dysgalactiae subsp. equisimilis infection.

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Keywords

19 strains
 
emm sequences
 
equisimilis
 
equisimilis infection
 
gene encoding SICG
 
group G carbohydrate
 
homolog
 
invasive disease
 
Molecular characterization
 
N-terminal sequence
 
S. dysgalactiae subsp
 
S. pyogenes
 
SICG
 
sicG possession
 
significant relationship
 
strains
 
Streptococcus pyogenes SIC