Position Statement: Definition of Traumatic Brain Injury

University of Cambridge, United Kingdom.
Archives of physical medicine and rehabilitation (Impact Factor: 2.57). 11/2010; 91(11):1637-40. DOI: 10.1016/j.apmr.2010.05.017
Source: PubMed


A clear, concise definition of traumatic brain injury (TBI) is fundamental for reporting, comparison, and interpretation of studies on TBI. Changing epidemiologic patterns, an increasing recognition of significance of mild TBI, and a better understanding of the subtler neurocognitive neuroaffective deficits that may result from these injuries make this need even more critical. The Demographics and Clinical Assessment Working Group of the International and Interagency Initiative toward Common Data Elements for Research on Traumatic Brain Injury and Psychological Health has therefore formed an expert group that proposes the following definition: In this article, we discuss criteria for considering or establishing a diagnosis of TBI, with a particular focus on the problems how a diagnosis of TBI can be made when patients present late after injury and how mild TBI may be differentiated from non-TBI causes with similar symptoms. Technologic advances in magnetic resonance imaging and the development of biomarkers offer potential for improving diagnostic accuracy in these situations.

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Available from: Andrew I R Maas, Oct 01, 2015
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    • "Team sports injuries (e.g., hockey, football) have been identified as the main source of TBI among youth, while falls and motor vehicle collisions are the main mechanisms of TBI among adults (Centre for Disease Control and Prevention, 2010; Coronado et al., 2011; Gilchrist, 2011; Ilie et al., 2013, 2015; Zernicke et al., 2009). TBI is a condition characterized by change in brain function that is caused by a hit or blow to the head by an external force (Menon et al., 2010). TBIs, including milder forms of the injury, may have disabling clinical outcomes (Coronado et al., 2011; Finkelstein et al., 2000; Ilie et al., 2013, 2014a,b; 2015; Dematteo et al., 2010). "
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    ABSTRACT: Objective: This study describes the association between lifetime traumatic brain injury (TBI) and attention deficit and hyperactivity disorder (ADHD) among Canadian adults. Method: A cross-sectional sample of 3993 Ontario adults aged 18 or older were surveyed by Computer Assisted Telephone Interviewing (CATI) throughout 2011 and 2012 as part of the CAMH Monitor, a rolling survey assessing the health, mental health and substance use of Ontario adults. TBI was defined as trauma to the head that resulted in loss of consciousness for at leastfive minutes or overnight hospitalization. ADHD was measured by the 6-item ASRS screener for adult ADHD, and self-reported history of diagnosed ADHD. Results: Among adults with a history of TBI, 6.6% (95% CI: 4.7, 9.4) screened ADHD positive, and 5.9% (95% CI: 3.6, 9.5) reported having been diagnosed with ADHD in their lifetime. Adults with lifetime TBI had significantly greater odds of scoring positive on the ADHD/ASRS screen (OR¼ 2.49, 95% CI: 1.54, 4.04), and of reporting a history of diagnosed ADHD (OR¼ 2.64, 95% CI: 1.40, 4.98) than without TBI, when holding values of sex, age, and education constant. Conclusion: Significant positive associations between lifetime TBI and both current and past ADHD were observed among adults in this population. More research to understand these associations, and their significance for the etiology and management of TBI and ADHD, is needed
    Journal of Psychiatric Research 08/2015; DOI:10.1016/j.jpsychires.2015.08.004 · 3.96 Impact Factor
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    • "Traumatic brain injury occurs when an external force causes an alteration in brain functions such as decreased level of consciousness , loss of memory, neurological deficits or any alteration in mental state at the time of the injury [8]. The diagnosis of TBI necessarily involves a severity assessment [9]. "
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    ABSTRACT: L’occurrence d’un traumatisme craniocérébral (TCC) est un problème de santé publique majeure. Les troubles du sommeil et de l’éveil sont parmi les symptômes les plus persistants et les plus déshabilitants à la suite d’un TCC. Or, les études empiriques portant sur l’apparition de ces symptômes, leur chronicisation et leur traitement demeurent non concluantes. Cette revue narrative a comme but de recenser le niveau de connaissance actuel sur la nature (objective et subjective) des troubles du sommeil et de l’éveil chez les patients TCC, en tenant compte de la sévérité du traumatisme et de la phase de rétablissement. Un but secondaire est de cibler les causes potentielles de ses perturbations. En général, bien que la présence de troubles du sommeil et de l’éveil dans toutes les études conduites auprès de patients TCC soit observée indépendamment de la sévérité du traumatisme, des signes objectivables de la présence de telles perturbations ne sont pas rapportés de façon consistante dans ces études. Des études supplémentaires semblent être requises afin de mieux comprendre la complexité des troubles du sommeil et de l’éveil chez les patients TCC et d’optimiser la récupération à court et à long terme chez cette clientèle par l’entremise d’interventions ciblées.
    Pathologie Biologie 10/2014; 62(5). DOI:10.1016/j.patbio.2014.05.014 · 1.20 Impact Factor
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    • "Traumatic brain injury (TBI) is defined as an alteration in brain function or evidence of brain pathology caused by an external force and is related with damage specifically to the brain [78]. An estimated 235,000 Americans are hospitalized annually for nonfatal TBI, and 1.1 million are treated in emergency departments, but, with 50,000 fatal cases every year, TBI is one of the leading causes of mortality among young people [79, 80]. "
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    ABSTRACT: Many diseases of the central nervous system are characterized and sometimes worsened by an intense inflammatory response in the affected tissue. It is now accepted that resolution of inflammation is an active process mediated by a group of mediators that can act in synchrony to switch the phenotype of cells, from a proinflammatory one to another that favors the return to homeostasis. This new genus of proresolving mediators includes resolvins, protectins, maresins, and lipoxins, the first to be discovered. In this short review we provide an overview of current knowledge into the cellular and molecular interactions of lipoxins in diseases of the central nervous system in which they appear to facilitate the resolution of inflammation, thus exerting a neuroprotective action.
    BioMed Research International 09/2014; 2014. DOI:10.1155/2014/316204 · 2.71 Impact Factor
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