Neoplasia of gallbladder and biliary epithelium

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 11/2010; 134(11):1621-7. DOI: 10.1043/2009-0580-RAR.1
Source: PubMed


Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients. Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis.
(1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
Current English literature related to gallbladder and biliary neoplasia.
Biliary glandular neoplasms show a wide spectrum of morphology and have many mimics. Careful examination of the histologic features of these lesions and familiarity with their morphology can help to achieve the correct diagnosis.

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    • "An atypical disordered proliferation of cuboidal or columnar epithelium showing loss of polarity and pseudostratification was regarded as dysplasia. We categorized dysplasia as low- or high-grade dysplasia according to the criteria by Katabi.8 While the criteria for low-grade dysplasia were mild nuclear enlargement, mild nuclear pseudostratification, and only minimal nuclear irregularities, the criteria for high-grade dysplasia were marked nuclear enlargement and irregularity, prominent nucleoli, mitosis, nuclear hyperchromasia, and loss of polarity. "
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