The Role of Mild Depression in Sleep Disturbance and Quality of Life in Parkinson’s Disease

Brain & Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia.
The Journal of neuropsychiatry and clinical neurosciences (Impact Factor: 2.82). 10/2010; 22(4):384-9. DOI: 10.1176/appi.neuropsych.22.4.384
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This study examined depressive symptoms, sleep disturbance, and quality of life in 35 patients with Parkinson's disease. Results showed that nocturnal sleep disturbance, depressive symptoms, and motor disease severity accounted for over two-thirds of the variance in quality of life scores. Depression was the largest predictor of quality of life, uniquely explaining 21% of the variance. Nocturnal sleep disturbance was associated with depressive symptoms as well as with daytime sleepiness. Overall, these data highlight the need to screen patients for even mild levels of depression because its relationship with sleep and quality of life are evident early in the disease course.

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Available from: Sharon L Naismith, May 26, 2015
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    • "Low mood, depression, and hallucinations affect quality of life, even after controlling for motor symptoms [2]. Apathy, anxiety, and depression are all associated with quality of life [1, 20, 21], with depression as the largest predictor [18, 22]. Psychosis in PD is more stressful for caregivers than motor dysfunction and is the greatest risk factor for nursing home placement [23–25]. "
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    ABSTRACT: Background. Neuropsychiatric symptoms are common in idiopathic Parkinson's disease (PD), and hospitalization for delirium, depression, psychosis, and anxiety is sometimes required. A minimal amount of data exists on these patients. Methods. Charts of all patients admitted to a psychiatric hospital between 2006 and 2009 with a diagnosis of PD were reviewed. Forty-three met entry criteria and were reviewed. Initial and discharge diagnoses, comorbid psychiatric diagnoses, length of stay, and living arrangements before and after hospitalization are described. Results. Consistent with previous research, this study showed evidence of comorbid psychiatric disorders within PD. Conclusions. The long-term goal of this area of study would be to reduce neuropsychiatric symptoms and improve quality of life in order to reduce inpatient hospital stays.
    Parkinson's Disease 03/2014; 2014(7):420240. DOI:10.1155/2014/420240 · 2.01 Impact Factor
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    • "However, it has become increasingly apparent that nonmotor features such as cognitive impairment, constipation, bladder dysfunction, sleep disorders, depression, anxiety, and psychosis are also significant [1]. Indeed, these symptoms, which are often poorly recognised and treated, can dominate in advanced PD accounting for significant disability, impaired quality of life, and reduced life expectancy [1, 2]. "
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    ABSTRACT: Mild Cognitive Impairment in Parkinson's Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition and accurate classification of PD-MCI could offer opportunities for novel therapeutic interventions. This review discusses current definitions for PD-MCI, the screening tools used, the pattern of cognitive deficits observed, and the predictors of cognitive decline and transition to Parkinson's Disease Dementia. Emerging biomarkers, which may aid diagnosis, are also explored and the role of novel treatment options is considered.
    Neurology Research International 07/2013; 2013:576091. DOI:10.1155/2013/576091
    • "Despite well-known sleep disturbances in PD, sleep has been a rare and mostly neglected topic in Parkinson research. The etiology of sleep problems in PD is not well-understood, as they may arise from the pathology of the disease or from other disease-related factors such as motor dysfunction, dopaminergic medication, and mood disturbances.[12–14] Different questionnaires were developed to assess the presence or absence of sleep disorders and also to provide a guide for response to treatment.[15–23] "
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    ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms. The latter are common and include autonomic dysfunction, cognitive impairment, and sleep difficulties. Many of the non-motor aspects of PD such as sleep disturbance are more common and significantly affect the day-to-day activities of patients and their quality of life. The most important aim of this study was to evaluate the sleep quality in patients with PD. This case-control study was performed on patients with PD referred to the Neurology Clinic of our teaching hospital in 2011. Thirty-four patients with PD and 34 healthy people as control group were enrolled in this study. Sleep quality of patients and control was evaluated by Parkinson's disease sleep scale (PDSS) questionnaire. PDSS is a reliable and valid tool to measure sleep disorders in PD. The mean total PDSS score in patient group was 55.29 (SD = 26.92) indicating moderate to severe sleep disturbances whereas, the mean total score in control group was 20.34 (SD = 10.65). Difference between the two groups' mean scores was significant (P < 0.05). Our study demonstrated that patients with PD experienced poorer nocturnal sleep quality than the control group.
    International journal of preventive medicine 05/2013; 4(Suppl 2):S229-33.
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