Article

Methylation of the TFPI2 gene is frequently detected in advanced gastric carcinoma.

Department of Surgery, Showa University Fujigaoka Hospital, Aoba-ku, Yokohama, Japan.
Anticancer research (impact factor: 1.73). 10/2010; 30(10):4131-3. pp.4131-3
Source: PubMed

ABSTRACT Recently, Glockner et al. identified the methylation of TFPI2 as a frequent event in human colorectal cancer using a gene expression array-based strategy.
Methylation status of the TFPI2 gene was examined in primary carcinomas and the corresponding normal tissues derived from 38 patients with gastric cancer using quantitative methylation-specific PCR (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated.
Aberrant methylation of the TFPI2 gene was detected in 7 out of 38 (18%) primary gastric carcinomas, suggesting that the methylation of TFPI2 is frequently observed in gastric carcinomas. The clinicopathological data were correlated with the methylation results. A significant difference was observed in maximal tumour size (p=0.0084), extent of tumour (p=0.0068), and TNM stage (p=0.0392).
TFPI2 is frequently methylated in advanced gastric carcinomas.

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Keywords

38 patients
 
Aberrant methylation
 
clinicopathological data
 
clinicopathological findings
 
corresponding normal tissues
 
frequent event
 
gastric cancer
 
gastric carcinomas
 
gene expression array-based strategy
 
human colorectal cancer
 
maximal tumour size
 
methylation
 
methylation results
 
Methylation status
 
primary carcinomas
 
qMSP
 
quantitative methylation-specific PCR
 

Kenji Hibi