Impact of viral load of hepatitis C on the incidence of hepatocellular carcinoma A population-based cohort study (JPHC Study)

National Cancer Center, Tokyo, Japan.
Cancer letters (Impact Factor: 5.62). 10/2010; 300(2):173-9. DOI: 10.1016/j.canlet.2010.10.002
Source: PubMed


Impact of viral load of HCV on the incidence of hepatocellular carcinoma was investigated using a population-based cohort consisting of 20,794 Japanese. A total of 114 newly arising cases of hepatocellular carcinoma were diagnosed during follow-up. Compared to the hepatitis virus-negative group, the hazard ratio (HR) of developing hepatocellular carcinoma was 35.8-fold higher in HCV monoinfection (95% confidence interval [CI], 20.7-62.7). A titer-dependent increase in risk was not identified. The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence.

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