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Biocatalysis - key to sustainable industrial chemistry

Sigma-Aldrich, Industriestrasse 25, CH-9470 Buchs, Switzerland.
Current Opinion in Biotechnology (Impact Factor: 8.04). 10/2010; 21(6):713-24. DOI: 10.1016/j.copbio.2010.09.016
Source: PubMed

ABSTRACT The ongoing trends to process improvements, cost reductions and increasing quality, safety, health and environment requirements of industrial chemical transformations have strengthened the translation of global biocatalysis research work into industrial applications. One focus has been on biocatalytic single-step reactions with one or two substrates, the identification of bottlenecks and molecular as well as engineering approaches to overcome these bottlenecks. Robust industrial procedures have been established along classes of biocatalytic single-step reactions. Multi-step reactions and multi-component reactions (MCRs) enable a bottom-up approach with biocatalytic reactions working together in one compartment and recations hindering each other within different compartments or steps. The understanding of the catalytic functions of known and new enzymes is key for the development of new sustainable chemical transformations.

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