Biocatalysis—Key to sustainable industrial chemistry

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Current Opinion in Biotechnology (Impact Factor: 7.12). 10/2010; 21(6):713-24. DOI: 10.1016/j.copbio.2010.09.016
Source: PubMed


The ongoing trends to process improvements, cost reductions and increasing quality, safety, health and environment requirements of industrial chemical transformations have strengthened the translation of global biocatalysis research work into industrial applications. One focus has been on biocatalytic single-step reactions with one or two substrates, the identification of bottlenecks and molecular as well as engineering approaches to overcome these bottlenecks. Robust industrial procedures have been established along classes of biocatalytic single-step reactions. Multi-step reactions and multi-component reactions (MCRs) enable a bottom-up approach with biocatalytic reactions working together in one compartment and recations hindering each other within different compartments or steps. The understanding of the catalytic functions of known and new enzymes is key for the development of new sustainable chemical transformations.

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Available from: Roland Wohlgemuth, Dec 31, 2014
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    • "In order to meet the demands of the pharmaceutical industry, many companies turned to bioconversions to replace parts of their chemical processes (Kieslich, 1997; Michels & Rosazza, 1999; Rogers, 1999; Wohlgemuth, 2010). "
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    ABSTRACT: Modern research has focused on the microbial transformation of a huge variety of organic compounds to obtain compounds of therapeutic and/or industrial interest. Microbial transformation is a useful tool for producing new compounds, as a consequence of the variety of reactions for natural products. This article describes the production of many important compounds by biotransformation. Emphasis is placed on reporting the metabolites that may be of special interest to the pharmaceutical and biotechnological industries, as well as the practical aspects of this work in the field of microbial transformations.
    Critical Reviews in Biotechnology 09/2015; DOI:10.3109/07388551.2015.1083943 · 7.18 Impact Factor
    • "Biocatalysts are whole microbial cells or enzymes that can be used in biochemical reactions of modern biotechnology. Some of these reactions have optimized or even replaced existing processes (Wohlgemuth, 2010; Resch et al., 2011). Interest in biocatalysts has recently increased with the growth and development of biotechnology as a strategy towards attaining a biobased economy. "
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    ABSTRACT: In the last decade, attention to extreme environments has increased because of interests to isolate previously unknown extremophilic microorganisms in pure culture and to profile their metabolites. Microorganisms that live in extreme environments produce extremozymes and extremolytes that have the potential to be valuable resources for the development of a bio-based economy through their application to white, red, and grey biotechnologies. Here, we provide an overview of extremophile ecology, and we review the most recent applications of microbial extremophiles and the extremozymes and extremolytes they produce to biotechnology.
    Applied Microbiology and Biotechnology 08/2015; 99(19). DOI:10.1007/s00253-015-6874-9 · 3.34 Impact Factor
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    • "Tomando en cuenta lo anterior, actualmente muchas aplicaciones industriales se ven apoyadas en gran medida por el uso de la tecnología enzimática, lo cual ha provocado que las ventas de enzimas a nivel mundial crezcan anualmente en aproximadamente un 7.5 % (Beilen y Li, 2002; Rasmussen y Morrissey, 2007; Ferraro y col. 2010; Wohlgemuth, 2010). Las enzimas del grupo de las hidrolasas, particularmente las proteasas, representan al menos el 60% de las ventas globales de enzimas en el mundo. "
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