Article

Naked dense bodies provoke depression.

Carl-Ludwig-Institute of Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.
Journal of Neuroscience (impact factor: 7.11). 10/2010; 30(43):14340-5. DOI:10.1523/JNEUROSCI.2495-10.2010 pp.14340-5
Source: PubMed

ABSTRACT At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brpnude, lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brpnude, electron-dense bodies were properly shaped, though entirely bare of synaptic vesicles. While basal glutamate release was unchanged, paired-pulse and sustained stimulation provoked depression. Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression.

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Keywords

active zone protein Bruchpilot
 
AZ cytomatrix
 
AZs
 
basal glutamate release
 
brpnude
 
C-terminal amino acids
 
hypomorphic allele
 
intramolecular precision
 
paired-pulse
 
presynaptic active zones
 
synaptic depression
 
unknown functional significance