Article

Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Journal of the American Chemical Society (impact factor: 9.91). 10/2010; 132(45):15846-8. DOI:10.1021/ja105937q pp.15846-8
Source: PubMed

ABSTRACT Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

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Keywords

azo bond
 
azo functional group
 
fluorescence imaging
 
hypoxia-sensitive near-infrared fluorescent probes
 
hypoxia-sensor moiety
 
large fluorescence increase
 
mice