Article

Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells.

Polyol Biotech Ltd, Granot Initiative Center, D.N. Hefer, Israel.
Archives for Dermatological Research (impact factor: 2.28). 10/2010; 303(4):239-46. DOI:10.1007/s00403-010-1088-6 pp.239-46
Source: PubMed

ABSTRACT Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.

0 0
 · 
0 Bookmarks
 · 
174 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

cell viability
 
DNA lesions
 
Exposing skin
 
harmful cellular cascades
 
human skin explants
 
IL-6
 
Introducing PFA
 
PFA
 
polyhydroxylated fatty alcohols
 
results support
 
unique lipid molecules
 
UV
 
UV-induced cellular damage
 
UV-induced skin damage
 
UVB
 
UVB-induced damage