Giant Basal Cell Carcinoma of the Breast Mimicking Paget's Disease: Complete Remission after Photodynamic Therapy
ABSTRACT Basal cell carcinoma (BCC) in the nipple area is extremely rare and can be mistaken for Paget's disease.
A 47-year-old woman complained of a slowly growing, scaly erythematous plaque around her right nipple which had developed over several years. Paget's disease of the breast was suspected. Biopsies revealed a superficial BCC. The maximum tumor thickness was measured as 1 mm. Considering the superficial character of the tumor, photodynamic therapy (PDT) as a non-invasive approach was performed. Complete remission (CR) with an excellent cosmetic result was achieved after 4 PDT sessions. In the follow-up, CR with no signs of a local recurrence was evident after more than 24 months.
In similar superficial cases of BCCs, non-invasive procedures such as PDT can be discussed as an alternative option to radical surgery or radiotherapy, with an excellent aesthetic outcome in carefully selected cases.
- SourceAvailable from: Maurizio Giuliani[Show abstract] [Hide abstract]
ABSTRACT: As the most common form of skin cancer, basal cell carcinoma (BCC) is typified by locally infiltrative growth and a very low risk of metastasis. On occasion, however, this otherwise indolent neoplasm may behave aggressively, demonstrating deep tissue invasion and a high rate of postsurgical recurrence. The pathogenesis and determinants of such tenacious growth are not completely understood. Only 1% of all BCC's achieve the status of 'giant', as defined in 1988 by the American Joint Committee on Cancer. In this article, the authors provide a comprehensive review of the scientific literature on giant basal cell carcinoma (GBCC) of the skin and report their experience with this rare tumour subtype.Journal of the European Academy of Dermatology and Venereology 12/2011; 26(8):942-52. DOI:10.1111/j.1468-3083.2011.04427.x · 3.11 Impact Factor