VEGF and refractive error.

Mannheim, Germany, Beijing, China.
Ophthalmology (Impact Factor: 5.56). 11/2010; 117(11):2234.e1. DOI: 10.1016/j.ophtha.2009.12.006
Source: PubMed
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    ABSTRACT: Purpose: To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats' disease. Methods: The clinical interventional study included 28 patients with Coats' disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats' disease was graded into four stages. Results: The mean aqueous VEGF level was significantly higher in the Coats' study group than in the control group (158 ± 88 versus 97 ± 21 pg/ml; p = 0.002). The VEGF concentrations increased significantly (p < 0.001) from 91 ± 32 pg/ml in Coats' disease stage 2 to 100 ± 37 pg/ml in stage 3A1, 185 ± 56 pg/ml in stage 3A2 to 256 ± 93 pg/ml in patients with stage 3B. Vascular endothelial growth factor concentrations in Coats' stage 2 and 3A1 did not differ significantly from the values in the control group. Parallel to the association with the stage of the diseases, the VEGF concentrations were significantly (p < 0.001) correlated with extent of exudative retinal detachment. Conclusions: Increasing severity of Coats' disease is significantly associated with intraocular VEGF concentrations. These results favour the intravitreal application of anti-VEGF drugs as medical therapy of Coats' diseases.
    Acta ophthalmologica 06/2013; · 2.44 Impact Factor
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    ABSTRACT: To summarize relevant evidence investigating the associations between refractive error and age-related macular degeneration (AMD). Systematic review and meta-analysis. We searched Medline, Web of Science, and Cochrane databases as well as the reference lists of retrieved articles to identify studies that met the inclusion criteria. Extracted data were combined using a random-effects meta-analysis. Studies that were pertinent to our topic but did not meet the criteria for quantitative analysis were reported in a systematic review instead. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between refractive error (hyperopia, myopia, per-diopter increase in spherical equivalent [SE] toward hyperopia, per-millimeter increase in axial length [AL]) and AMD (early and late, prevalent and incident). Fourteen studies comprising over 5800 patients were eligible. Significant associations were found between hyperopia, myopia, per-diopter increase in SE, per-millimeter increase in AL, and prevalent early AMD. The pooled ORs and 95% CIs were 1.13 (1.06-1.20), 0.75 (0.56-0.94), 1.10 (1.07-1.14), and 0.79 (0.73-0.85), respectively. The per-diopter increase in SE was also significantly associated with early AMD incidence (OR, 1.06; 95% CI, 1.02-1.10). However, no significant association was found between hyperopia or myopia and early AMD incidence. Furthermore, neither prevalent nor incident late AMD was associated with refractive error. Considerable heterogeneity was found among studies investigating the association between myopia and prevalent early AMD (P = 0.001, I2 = 72.2%). Geographic location might play a role; the heterogeneity became non-significant after stratifying these studies into Asian and non-Asian subgroups. Refractive error is associated with early AMD but not with late AMD. More large-scale longitudinal studies are needed to further investigate such associations.
    PLoS ONE 01/2014; 9(3):e90897. · 3.53 Impact Factor
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    ABSTRACT: Purpose: To determine the relationship between axial length (AL), retinal function, and relative oxygen (O2) consumption to better understand the protective effect of axial elongation on diabetic retinopathy development. Methods: Measurements of AL, multifocal electroretinogram (mfERG) and relative O2 consumption (difference between arteriolar and venular O2 saturation levels or A-V difference) were performed on 50 healthy individuals. The relationships between AL, mfERG amplitude and A-V difference were analysed using linear regression models. Path analysis was performed to determine the direct and indirect effects (via mfERG amplitude) of AL on A-V difference. Results: mfERG P1 amplitude was positively associated with A-V difference (β = 0.33; 95% confidence interval (CI): 0.23 to 0.42). Increased AL was significantly associated with a decrease in A-V difference (β = -1.08; 95%CI: -1.52 to -0.65) as well as a decrease in retinal function (β= -3.14, 95%CI -4.07 to -2.20). Path analysis models including AL (study factor), retinal function (intermediate variable) and A-V difference (outcome variable) showed that AL had little direct association with A-V difference (βp = -0.002), while the indirect effect of AL on A-V difference via changes in retinal function were substantial (βp = -0.51). Conclusion: In eyes with longer AL, the reduction in A-V difference is explained by the parallel reduction in retinal function. These findings suggest that longer eyes have decreased retinal function and O2 consumption, and thus are relatively less hypoxic in the presence of diabetes, which may partly explain the reduced risk of DR in these eyes.
    Investigative ophthalmology & visual science 10/2013; · 3.43 Impact Factor