VEGF and refractive error
Mannheim, Germany, Beijing, China. Ophthalmology
(Impact Factor: 6.14).
11/2010; 117(11):2234.e1. DOI: 10.1016/j.ophtha.2009.12.006
Available from: Chenjin Jin
- "In addition, the relative hypoxic conditions in hyperopic eyes may cause increased cytokine production. Jonas et al  reported that the intraocular concentration of vascular endothelial growth factor (VEGF) decreased significantly with increasing myopia, and as a corollary, with increasing AL. The larger ocular volume in myopic eyes was thought to dilute intraocular VEGF, leading to decreased angiogenesis. "
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ABSTRACT: To summarize relevant evidence investigating the associations between refractive error and age-related macular degeneration (AMD).
Systematic review and meta-analysis.
We searched Medline, Web of Science, and Cochrane databases as well as the reference lists of retrieved articles to identify studies that met the inclusion criteria. Extracted data were combined using a random-effects meta-analysis. Studies that were pertinent to our topic but did not meet the criteria for quantitative analysis were reported in a systematic review instead.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between refractive error (hyperopia, myopia, per-diopter increase in spherical equivalent [SE] toward hyperopia, per-millimeter increase in axial length [AL]) and AMD (early and late, prevalent and incident).
Fourteen studies comprising over 5800 patients were eligible. Significant associations were found between hyperopia, myopia, per-diopter increase in SE, per-millimeter increase in AL, and prevalent early AMD. The pooled ORs and 95% CIs were 1.13 (1.06-1.20), 0.75 (0.56-0.94), 1.10 (1.07-1.14), and 0.79 (0.73-0.85), respectively. The per-diopter increase in SE was also significantly associated with early AMD incidence (OR, 1.06; 95% CI, 1.02-1.10). However, no significant association was found between hyperopia or myopia and early AMD incidence. Furthermore, neither prevalent nor incident late AMD was associated with refractive error. Considerable heterogeneity was found among studies investigating the association between myopia and prevalent early AMD (P = 0.001, I2 = 72.2%). Geographic location might play a role; the heterogeneity became non-significant after stratifying these studies into Asian and non-Asian subgroups.
Refractive error is associated with early AMD but not with late AMD. More large-scale longitudinal studies are needed to further investigate such associations.
PLoS ONE 03/2014; 9(3):e90897. DOI:10.1371/journal.pone.0090897 · 3.23 Impact Factor
Available from: Young Joo Shin
- "There has been several studies about the role of VEDF and PEDF in development of CNV, and anti-VEGF therapy has been used for treating CNV. In the previous study [17,18], it has been reported that the VEGF concentration in the aqueous humor of patients with myopic CNV is lower than in normal controls  and there are significantly lower concentrations of VEGF in myopic eyes than in hyperopic eyes . However, it is unknown whether these results are due to dilution effect in larger eyes or degeneration of retinal pigment epithelium (RPE) and choroid. "
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ABSTRACT: To compare the aqueous humor levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in high myopic eyes and control eyes.
Aqueous humor samples were collected from 21 highly myopic eyes of 20 patients (high myopia group) and from 30 cataract eyes of 30 patients with no choroidal neovascularization (CNV) or other ocular or systemic diseases (control group). Of the 21 high myopic eyes, 13 had no complications secondary to high myopia (high myopia with no complications group), 3 had posterior staphyloma (high myopia with staphyloma group), and 5 had chorioretinal atrophy (high myopia with chorioretinal atrophy group). The aqueous humor levels of VEGF and PEDF were determined by using commercially available enzyme-linked immunosorbent assay kits.
Aqueous humor levels of VEGF were significantly lower in the high myopia group compared to that in the control group (p<0.001). VEGF levels decreased with an increase in the axial length (p<0.001). PEDF levels tended to be higher in the high myopia group compared to that in the control group; however, the difference was not significant. Three high myopia groups had significantly lower VEGF/PEDF ratios than the control group (p=0.000, 0.002, and 0.005).
Aqueous humor levels of VEGF in the high myopia group were significantly lower than those in the control group. The differing levels of VEGF and PEDF in the high myopia and control groups suggest that high myopia disrupts the VEGF/PEDF balance in retinal pigment epithelium (RPE) cells.
Molecular vision 08/2012; 18:2265-70. · 1.99 Impact Factor
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ABSTRACT: Choroidal neovascularisation secondary to pathological myopia is the most common cause of severe visual impairment in myopic patients younger than 50 years old. The typical features of myopic CNV in contrast to age-related macular degeneration as well as the anatomic characteristics have an impact on the parameters of the baseline and follow-up examinations. As the usually small fibrovascular lesions show a rapid progression in the spontaneous course of the disease and lead to irreversible damage to the photoreceptors, prompt initiation of treatment is mandatory. The superior functional results of anti-VEGF drugs provide the reason for the first-line status of this treatment modality. Increasing safety data and consistent results of prospective pilot trials have proved photodynamic therapy to be inferior. There are signs that PRN-based treatment algorithms may allow for less frequent dosing than in other retinal diseases.
Klinische Monatsblätter für Augenheilkunde 09/2011; 228(9):762-70. DOI:10.1055/s-0031-1281583 · 0.46 Impact Factor
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