Article

[TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease].

School of Life Science and Technology, Xi'an Jiaotong University, College of Medicine, Xi'an 710049, China.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 10/2010; 30(10):2246-8. pp.2246-8
Source: PubMed

ABSTRACT To study the association between single nucleotide polymorphisms of thioredoxin reductase-2 (TrxR2) gene and the susceptibility to Kashin-Beck disease (KBD).
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotype frequencies of rs5748469 in TrxR2 gene in 84 KBD patients and 109 healthy control subjects.
The genotype frequencies of A/A, A/C, and C/C in the KBD patients were 83.33%, 15.48% and 1.19%, as compared with the frequencies of 74.31%, 25.69%, and 0.00% in the healthy control, respectively, showing no significant difference in the single nucleotide polymorphisms of TrxR2 gene between the two groups (P=0.13).
No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to KBD.

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Keywords

109 healthy control subjects
 
84 KBD patients
 
genotype frequencies
 
KBD
 
KBD patients
 
obvious correlation
 
Polymerase chain reaction-restriction fragment length polymorphism
 
single nucleotide polymorphisms
 
susceptibility
 
TrxR2
 
TrxR2 gene
 
two groups