Disseminated Paracoccidioidomycosis in a Southern Two-Toed Sloth (Choloepus didactylus)

Laboratorio Central Regional de Monterrey, Comité para el Fomento y Protección Pecuaria del Estado de Nuevo León, A.C., Terrenos de la Exposición Ganadera, Ciudad Guadalupe, Nuevo León, Mexico.
Journal of comparative pathology (Impact Factor: 1.14). 10/2010; 144(2-3):231-4. DOI: 10.1016/j.jcpa.2010.08.012
Source: PubMed


A Southern two-toed sloth (Choloepus didactylus), originally acquired from French Guiana, died while maintained in quarantine in a pet store in Monterrey, Mexico. Large yeast cells with multiple buds compatible with Paracoccidioides brasiliensis were observed in disseminated granulomatous lesions in the lungs, liver, spleen and kidney. Transmission electron microscopical examination supported the diagnosis. This is the first report of paracoccidioidomycosis in a two-toed sloth.

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    • "This disease mainly affects male rural workers and is endemic from Mexico to Argentina (Franco et al. 1993). In its mycelial form, P. brasiliensis lives saprophytically on the ground, producing such propagules as arthroconidia and aleuroconidia that can infect humans (Franco et al. 1994), dogs (Ricci et al. 2004, Farias et al. 2005), armadillos (Naiff et al. 1986, Bagagli et al. 1998, 2003, Corredor et al. 1999) and sloths (Trejo-Cháves et al. 2011). The inhalation of infective fungal propagules present in the environment is believed to be the route of infection in both human and non-human vertebrate hosts (McEwen et al. 1987). "
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