Article

The redox status in rats treated with flaxseed oil and lead-induced hepatotoxicity.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
Biological trace element research (impact factor: 1.92). 10/2010; 143(1):457-67. DOI:10.1007/s12011-010-8882-z pp.457-67
Source: PubMed

ABSTRACT Lead is a persistent environmental pollutant, and its toxicity continues to be a major health problem due to its interference with natural environment. In the present study, we have evaluated the effect of flaxseed oil on lead acetate-mediated hepatic oxidative stress and toxicity in rats. Lead acetate enhanced lipid peroxidation and nitric oxide production in both serum and liver with concomitant reduction in glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities, these findings were associated with DNA fragmentation. In addition, lead acetate caused liver injury as indicated by histopathological changed of the liver with an elevation in total bilirubin, serum alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, and alkaline phosphatase. Treatment of rats with flaxseed oil resulted in marked improvement in most of the studied parameters as well as histopathological features. On the basis of the above results it can hypothesized that flaxseed oil is a natural product can be protect against lead acetate-mediated hepatic cytotoxicity.

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  • Article: The protective effect of flaxseed oil on lead acetate-induced renal toxicity in rats.
    Ahmed E Abdel Moneim, Mohamed A Dkhil, Saleh Al-Quraishy
    [show abstract] [hide abstract]
    ABSTRACT: Lead is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans. Here, we investigated the effects of flaxseed oil (1000 mg/kg) on the outcome of renal cytotoxicity induced by lead acetate (20mg/kg) in male rats. Lead induced injury of the renal tissue. This was evidenced (i) as increases in lead concentration in the kidney, (ii) as increases in the histopathological damage of the renal tissue, (iii) as increases in uric acid, urea and creatinine, (iv) as increases in lipid peroxidation, nitric oxide and reactive oxygen species, and (v) as lowered glutathione levels and decreased activities of catalase and superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase, respectively. All these lead-induced parameters were significantly altered during flaxseed oil treatment. Therefore, our study suggests the role of flaxseed oil in limiting renal cytotoxicity-induced by lead acetate as a model for lead toxicity.
    Journal of hazardous materials 08/2011; 194:250-5. · 4.14 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

alkaline phosphatase
 
DNA fragmentation
 
elevation
 
flaxseed oil
 
glutathione
 
glutathione peroxidase activities
 
glutathione reductase
 
glutathione-S-transferase
 
histopathological features
 
lead acetate-mediated hepatic cytotoxicity
 
lead acetate-mediated hepatic oxidative stress
 
lipid peroxidation
 
liver injury
 
major health problem
 
natural environment
 
natural product
 
persistent environmental pollutant
 
serum alanine aminotransferase
 
studied parameters
 
total bilirubin