Aggression in children and adolescents with ASD: Prevalence and risk factors. Journal of Autism and Developmental Disorders, 41, 926-937

Department of Health Psychology and Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, 205 Portland Street, Suite 110, Columbia, MO 65211, USA.
Journal of Autism and Developmental Disorders (Impact Factor: 3.06). 10/2010; 41(7):926-37. DOI: 10.1007/s10803-010-1118-4
Source: PubMed

ABSTRACT The prevalence of and risk factors for aggression were examined in 1,380 children and adolescents with autism spectrum disorders (ASD). Prevalence was high, with parents reporting that 68% had demonstrated aggression to a caregiver and 49% to non-caregivers. Overall, aggression was not associated with clinician observed severity of ASD symptoms, intellectual functioning, gender, marital status, parental educational level, or aspects of communication. Individuals who are younger, come from a higher income family, have more parent reported social/communication problems, or engage in repetitive behaviors were more likely to demonstrate aggression. Given the significant impact of aggression on individual and family outcomes, it is hoped that this knowledge will inform more targeted intervention efforts.

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    • "Aggression and irritability are major symptom dimensions in autism spectrum disorder (ASD), with some estimates of prevalence as high as 68 % (Kanne and Mazurek 2011) and greater prevalence in individuals with low-cognitive ability (Hartley et al. 2008). It is argued that the optimal management of these symptoms includes both behavioral and pharmacological interventions (McDougle et al. 2003), with the latter often constituting the only treatment option in settings where there is limited knowledge and capacity for implementing behavioral strategies. "
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    ABSTRACT: Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted.
    Journal of Autism and Developmental Disorders 05/2015; DOI:10.1007/s10803-015-2471-0 · 3.06 Impact Factor
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    • "Sometimes, children behave cobative due to fear of inability to deal with emotions, especially frustration and are incapable to verbalize the situation efficiently. Other factors including environmental influences, unrelieved stress, lack of appropriate problem solving skills and coping strategies can also result in aggressive behaviors (Kanne & Mazurek, 2011). "
    Journal of Pakistan Medical Students 11/2014;
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    • "With regard to language ability, receptive and expressive language levels have been shown to be negatively associated with behavior problems (Dominick et al., 2007; McTiernan, et al., 2011; Park, Yelland, Taffe, & Gray, 2012). However, Kanne and Mazurek (2011) found that level of intellectual functioning and language ability were not predictive of aggressive behaviors in children and adolescents with ASD. Park and colleagues (2012) also found no significant association between structural language skills and behavior problems. Concerning age effects, mixed findings have been reported. "
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    ABSTRACT: Research has clearly demonstrated that behavior problems are common among children with ASD. These co-occurring behavior problems place children with ASD and their families at risk for a range of negative outcomes. This questionnaire study aimed to investigate whether and how age, gender, and communication difficulties at the child level and parenting behaviors at the family level are associated with externalizing and internalizing problems among children with ASD (n = 206) and without ASD (n = 187) aged 6–12 years. Results indicated that pragmatic language difficulties of the child and negative controlling parenting behaviors both made a significant and unique contribution to externalizing behavior problems for the ASD group. In the control group, chronological age and pragmatic language difficulties were the most robust concurrent predictors of externalizing problems. With regard to internalizing problems, pragmatic language difficulties and ASD adapted parenting behaviors were significant predictors for both the ASD and control group.
    Research in Autism Spectrum Disorders 06/2014; 8(6):716–725. DOI:10.1016/j.rasd.2014.03.008 · 2.96 Impact Factor
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