Calcium channel blockers and biliary pancreatitis.
Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.Scandinavian Journal of Gastroenterology (Impact Factor: 2.33). 10/2010; 46(2):253-4. DOI: 10.3109/00365521.2010.525719
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ABSTRACT: Nifedipine has been used in the treatment of sphincter of Oddi dyskinesia, a biliary disease characterized by upper abdominal pains and increased pressure in the sphincter. The effects of other calcium channel antagonists on sphincter of Oddi have not been elucidated. We compared the effects of three calcium blockers with differing smooth muscle selectivity (verapamil, nifedipine and felodipine) on human sphincter of Oddi contractions. Transverse sections of the sphincter obtained from five patients undergoing Whipple resection were studied in an organ bath chamber in vitro. All three calcium blockers significantly (>50%) inhibited the acetylcholine-induced and KCl-induced sphincter contractions in a dose-dependent manner. Both nifedipine and felodipine were more potent than verapamil in inhibiting the acetylcholine-induced contractions, whereas only nifedipine, but not felodipine, reduced the KCl-elicited contractions more than verapamil. The smooth muscle selective calcium channel antagonists are potent inhibitors of human sphincter of Oddi contractions. Although nifedipine is, to date, the only agent studied in clinical settings, other dihydropyridines are also likely to be useful in sphincter of Oddi dyskinesia.Scandinavian Journal of Gastroenterology 12/2005; 40(12):1394-7. · 2.33 Impact Factor
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ABSTRACT: The effect of nifedipine on sphincter of Oddi (SO) motor activity was determined by endoscopic manometry. Sphincter of Oddi pressures and motor function were compared in 21 healthy volunteers and in 9 patients with SO dyskinesia. The effects of sublingual doses of 10 or 20 mg of nifedipine were compared with placebo. Neither placebo nor 10 mg of nifedipine produced any effect on SO motor activity. In healthy volunteers 20 mg of nifedipine produced a moderate but significant decrease in basal SO pressure from 12.0 to 6.7 mmHg as well as in the amplitude, duration, and frequency of phasic contractions. In patients with SO dyskinesia 20 mg of nifedipine also resulted in a significant but more profound decrease of the basal SO pressure from 47.1 to 17.3 mmHg as well as in a decrease of amplitude, duration, and frequency of the phasic contractions. Neither placebo nor 10 or 20 mg of nifedipine has any effect on the sequence of phasic contractions. In summary, nifedipine may have a possible therapeutic role in the treatment of SO dyskinesia.Gastroenterology 11/1988; 95(4):1050-5. · 12.82 Impact Factor
- Cholescintigraphic evaluation of the effect of nifedipine upon bile drainage in patients suffering from type II sphincter of Oddi dyskinesia. Hepato Gastroenterol.
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