Insider Influence on ErbB Activity

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Cell (Impact Factor: 32.24). 10/2010; 143(2):181-2. DOI: 10.1016/j.cell.2010.09.042
Source: PubMed


The receptor tyrosine kinase ErbB is activated by ligand-induced dimerization, leading to transphosphorylation of the cytoplasmic kinase domains. Bill et al. (2010) now demonstrate that transphosphorylation can be modulated from within the cell by the cytoplasmic protein cytohesin, providing new insights into ErbB-dependent processes during normal development and cancer.

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